Nitroglycerin and Viagra – Is There Any Chance That They Can Work Together Safely?

Any combination of Viagra and Nitroglycerin within 24 hours is called fatal. Does it mean you have no chance for ED treatment (more about ed treatment at www.mycanadianpharmacyrx.com/erectile-dysfunction), while you take nitrates? A research must be done to learn the truth. Shall we?

Viagra is regarded as a drug that does more than helping men to cope with ED. Today the medication is also known for influencing heart even of health men, not speaking about the ones who have or had heart-related conditions. When a sick man takes nitroglycerin and Viagra, his risks for stroke, heart attack and even death increase. Does this mean that these two meds should never be combined?

Viagra and Heart Patients: Clinical Observations

Viagra and Heart Patients

It is a know fact that Viagra was discovered as a drug for heart-related issues treatment. And then clinical trials showed its effects in cases of ED. But let’s get back to its original purpose. Multiple short- and long-term studies were conducted to investigate the influence of Viagra on one’s heart. Here are several results:

Viagra and pulmonary vascular resistance: in case of primary pulmonary hypertension Viagra has selective vasodilatory results in the pulmonary vasculature, when compared to those of inhaled NO. Sildenafil improved the exercise capacity, functional capacity as well as resting hemodynamics in patients with PAH. The information on a long-term use of the medication in heart patients is limited, yet still the chemical’s effect on aerobic efficacy and artery pressure are sustained within six months;

Viagra and vascular function: Viagra is associated with endothelial function improvements in patients with heart failure. It improves the vascular function as well as pulmonary vascular resistance;

Viagra and cardiac response to stress: inhibition of the PDE5 enzyme is very important. It has essential effects that limit myocardial remodeling in response to stress. These effects are anti-apoptotic, ischemic preconditioning and antihypertrophic. Sildenafil limits the size of myocardial infarction that is generated during reperfusion.

When certain doses are prescribed for the heart condition treatment, Viagra may be effective, but one should be careful when combining it with nitrates, especially nitroglycerine.

What Does FDA Say About Viagra for ED and Nitroglycerine?

The Food and Drug Administration warns against the use of Viagra for ED treatment, while nitroglycerine is administered for heart issues. And believe it, there are many reasons for concern.

Stage 1: Viagra and nitroglycerin affect the muscles that control the size of blood vessels and make them relax. When the muscles are relaxed, the vessels start enlarging and provoke the drop in man’s blood pressure. If combined, both medications have greater effects than when taken separately. Muscle relaxation is significant and so is the blood pressure drop, which leads to fainting and can even be fatal.

Stage 2: A really dramatic drop in pressure is common in men with angina pectoris or heart pain in other words. During this condition a bit higher blood pressure is of great importance to supply enough blood to the bodily systems. When the pressure decreases, the blood flow to the heart is limited and it becomes the reason for a heart attack.Viagra for ED and Nitroglycerine

! If you take nitroglycerine, you should not take Viagra pills. When Viagra appeared on the market in 1998, 130 men died because of lack of medical knowledge and poor tips and recommendations provided by their doctors. 16 of them died because of a Viagra-nitroglycerine combination.

Stage 3: Sexual activity increases risks of complications in patients with angina pectoris. When a man takes Viagra for ED treatment, his risks increase and may lead to death.

Nitroglycerine and Viagra: the Mechanism for Hypotension

Here are top 4 facts that you need to know about a Viagra and nitroglycerine combination:

  • ED sufferers usually have an underlying condition called a coronary artery disease. It always requires the use of nitroglycerine products that treat chest pain;
  • Nitroglycerine and Viagra both act to cause the vasodilation of blood vessels;
  • This PDE5 inhibitor interacts with nitroglycerine and decreases the metabolism of NO induced activation of cGMP. Thus, it allows more cGMP mediated muscle vasodilation or relaxation;
  • If an ED patient takes nitroglycerine along with Viagra, a significant blood drop is only one of the mildest side effects that he experiences.

 It doesn’t matter much whether nitroglycerine dosage is low or high, it is still converted into NO in the body. It helps in cases of chest pain treatment in patients with IHD. As long as the ischemic heart disease results in decreased blood perfusion to the heart, nitroglycerine administration dilates the vessels, increases perfusion and reduces angina.

 

Untitled-1Co-administration of a PDE5 inhibitor with nitroglycerine has to do with the effects on cGMP. When they administered within 24 hours, the PDE5 inhibitor prevents the breakdown of NO which increases cGMP. Thus, the greater vasodilation becomes the main result. When accompanied by the blood pressure reduction, it can be fatal.

So, does it mean that there is no chance for Viagra and nitroglycerin to be taken together safely? It means that this combination can lead to severe side effects and even death, BUT if the doses are adjusted by a professional and you don’t take both medicines during the same 24 hours’ period, there is a rare chance to experience benefits from both drugs and side effects from neither of them.

Article by My Canadian Pharmacy Team: http://www.mycanadianpharmacyrx.com