Canadian Pharmacy mycanadianpharmacyrx.com specializes in a wide range of medicines for erectile dysfunction. Our service is focused on distribution of this kind of products. Nevertheless, following the results of previous month, we have developed TOP 5 rating consisting of new most popular medications among which you may find not only ED medicines. Let us examine each of them in greater details.
1. Cymbalta (Duloxetine)
Cymbalta is a medicine with anti-depressive effect. It contains active substance, duloxetine which is a combined reuptake inhibitor of epinephrine and serotonin. Duloxetine slightly inhibits dopamine reuptake. It doesn’t have any affinity of histamine, cholinoceptive, dopamine and adrenergic receptors. The efficiency of the drug in depression treatment is explained by inhibition of epinephrine and serotonin reuptake which causes noradrenergic and serotonergic neurotransmission in central nervous system. Cymbalta has also analgesic action which theoretically occurs because of deceleration of transmission of algetic impulses in central nervous system.
Cymbalta is indicative in the following cases:
- Algetic form of diabetic neuropathy;
- Generalized anxiety disorder.
Cymbalta is taken perorally regardless of food acceptance. The recommended initial dose makes 60mg once per day. If necessary, the dose may be enlarged from 60 mg once a day to maximal dose of 120mg in two intakes. Systematic estimation of medicine safety in dosage of 120mg was not conducted.
Cymbalta is counter-indicative for therapy of the patients with lack of tolerability to active or auxiliary components of capsules.
Cymbalta is also prohibited in the following cases:
- Unstable hypertension (with taking into account of hypertensive crisis risk);
- Impaired renal function (filtration indicators lower than 30ml/min);
- Hepatic pathologies;
- Duloxetine’s intake is strictly prohibited for patients treated with nonreversible non-selective MAO inhibitors (duloxetine’s intake is also prohibited within two weeks of treatment with such medications);
- Duloxetine intake is contraindicative on the top of therapy with fluvoxamine, enoxacin, and ciprofloxacin (considering significant influence of these medications on CYP1 A2).
Cymbalta is not for pediatric use. It should also be prescribed with care for patients with underlying risk of suicide (such patients must stay under constant control, since the suicidal attempts are not excluded especially at the beginning of treatment course).
Besides, Cymbalta is prescribed with care in case of:
- epileptic seizure, bipolar disorders and mania (in past medical history as well);
- ocular hypertension and danger of acute narrow-angle glaucoma;
- arterial hypertension, cardiac pathologies, arrhythmia, etc.;
- High risk of hyponatremia;
- Intake of medicines with hepatotoxic action.
While treatment with duloxetine, it is not recommended to control potentially dangerous types of machines.
2. Cialis Black 800mg
Cialis Black is designed for patients suffering from erectile dysfunction. Black Cialis active substance is tadalafil contained in dosage of 200 mg. The drug is considered to be one of the most efficient solutions for erectile dysfunction treatment in comparison with other PDE5 inhibitors. Its color cannot be confounded with any generic of Cialis.
Black Cialis is indicative in only one case – erectile dysfunction of any origin, severity level and at any age group. ED conditions imply cases when penis cannot get hard enough and become erected for a fully-realized sexual intercourse performance. But it is worth mentioning that Black Cialis is effective only in case of sexual stimulation.
Absence of weakness of erection may occur due to the following factors:
- organic erectile dysfunction;
- spinal cord trauma;
- psycho-emotional disorders hypertension;
- removed prostatic gland.
So, what’s the principle of Black Cialis functioning? The medical agent is capable of influencing the key impulse which takes a special part in sexual excitement. When a man is sexually excited, penis vessels become enlarged and receive a larger amount of blood causing penis erection. So, if blood vessels fail to be filled with blood, erection is not achieved. Cialis Black is a drug enhancing blood content in penis which results in natural steady erection. Enhanced blood supply to penis occurs due to vasorelaxation under the influence of a special substance, cyclic guanosine monophosphate. But it should be noted that cyclic guanosine monophosphate gets quickly destroyed by phosphodiesterase of 5 type (PDE5). Tadalafil inhibits (slows down) functioning of PDE5 resulting in preservation of cyclic guanosine monophosphate which affects a prolonged time relaxing blood vessels and enables to fill penis with blood for normal erection. Thus, according to its clinical action Cialis Black is a vasodilator.
Black Cialis is distinguished by its short onset time, it needs just 15-30 minutes to take action. The effect lasts 36 hours during which you are able to have sexual intercourse as much as you want. Elderly people may also take Black Cialis strictly observing the instruction. Minimal daily dosage is one pill a day. It is strictly prohibited to take Black Cialis oftener than one time per day.
Cialis Black is not to be taken if a patient takes medicines containing organic nitrates or a patient is under 18 years. Black Cialis is not to be taken by women as well.
Bear in mind that:
- Notwithstanding the fact that Black Cialis is on the open market, you should consult a specialist before its usage.
- This medicine is not recommended for patients suffering from cardiac angina, since boost of sexual activity influences adversely the overall condition and working capacity of heart-vascular system of a man.
- If you apply medicines for erectile dysfunction, you shouldn’t start taking Black Cialis, since it is prohibited to combine two drugs boosting erection.
3. Suhagra 100mg
Suhagra copes easily with erectile dysfunction regardless of severity level. Its active substance, sildenafil is contained in quantity of 100mg which is a maximal daily dosage allowing patients to achieve perfect results and is not harmful for health. Signals sent during sexual excitement go to sexual system and launch the process of glucan glucosyltransferase release. As a result, unstriated muscles of penis get relaxed. In non-erected state the penis muscles deflate. Therefore, blood flows there in minimal quantity. Cavernous bodies get filled with blood during a full relaxation of muscles resulting in erection. Upon finishing of sexual intercourse, a special enzyme PDE5 launches the reverse process of destruction of enzymes responsible for erection. Suhagra blocks selectively this enzyme and promotes long-standing and stable erection.
When it comes to advantages of Suhagra, it is important to mention the following:
- Dosage of active substance in one tablet is optimal and not disturbing the margin of safety as well;
- Qualitative improvement of erection is guaranteed by medicine’s manufacturer;
- The tablets intake contributes to reduction of interim between sexual intercourses and quick restoration of strength.
There are no special rules or serious restrictions while taking this generic, but it is worth bearing in mind that one tablet contains a maximum daily dosage of sildenafil. Therefore, Suhagra is not recommended to be taken oftener than once a day. It is better to drink the medicine with a glass of water 60 minutes before expected sexual intercourse. Fasted intake of Suhagra allows achieving maximal effect and accelerate the action rate of the drug. Suhagra should not be combined with fat food and strong alcohol. Emotional sexual excitement is a binding condition for obtaining of maximum results. Men over age of 65 years, should not take limiting dose of sildenafil, since it may result in negative consequences.
Suhagra should be taken with care in the following cases:
- Penis deformations;
- Diseases which may cause bleeding;
- Severe degrees of peptic ulcer disease;
- Cancer lesion in blood;
- Pronounced anemia.
Suhagra is counter-indicative to those who are hypersensitive to medicine’s ingredients. Suhagra cannot be used by persons who have heart or apoplectic attacks in medical history, as well as by those who suffer from arrhythmia, hypotension and hypertension. The medicine is compatible with nitrates and nitrogen oxide donors.
4. Viagra Plus (Generic Viagra / Sildenafil)
Viagra Plus is known as one of the most popular medicines on pharmaceutic market. Its efficiency in struggle against erectile dysfunction is time-honored and doesn’t require additional affirmation. Viagra Plus is enhanced by force of herbs. It is issued in the form of tablets the intake of which provides maximal blood supply to penis during sexual excitement.
The list of Viagra Plus advantages is quite large:
- Viagra Plus action has a positive impact on the overall condition of organism;
- Blood circulation in penis gets enhanced;
- The process of sexual response enhances;
- Chondrotropic hormones release is activated;
- Sexual activity increases;
- Spermacytogenesis improves.
One of the main active ingredients of Viagra Plus is ginseng which is a natural stimulant of endocrine system activity. Besides, it accelerates metabolic process in gastro-intestinal tract, strengthens heart and central nervous system. Enhanced sexual desire and erection are guaranteed by sildenafil the proportion of which in Viagra Plus makes 25% along with vitamins.
The composition of Viagra Plus includes:
- Sildenafil – PDE5 inhibitor relaxing muscles and enhancing blood supply in sexual organs;
- Ginseng – fortifies the immune system, helps manage stress, stimulates muscles and improves overall physical characteristics;
- L-arginine – participates actively in production of nitrogen oxide by organism relaxing blood vessels and stimulating prolactin release;
- Vitamin B12 – participates actively in production of blood corpuscles and formation of sound genetic material;
- Vitamin B6 – antioxidant which is essential for processing of amino acids, decrease of cholesterol level in blood and prevention from atherosclerosis.
- Folic acid – is an important participant of the process of DNA molecules synthesis and production of blood corpuscles which maintains working capacity of brain cells.
Viagra Plus is counter-indicative is the following cases:
- Allergy to one or several components;
- Counter-indications of excessive sexual activity;
- Intake of nitrates (isosorbide, nitroglycerin);
- Intake of stimulants (amyl nitrite, popper).
In case you have painful erection, allergy symptoms, vision or hearing impairment, arrhythmia, chest pains, diarrhea, vertigo, you should seek for immediate medical attendance.
5. Synthroid (Levothyroxine Sodium)
Synthroid is thyroid hormone produced synthetically which has the same effect as endogen hormone thyroxin-4 (T-4). Thyroid hormones are generally responsible for rate control of metabolic activity and play important role for human organism. When the hormonal drugs for thyroid body are prescribed, the metabolic activity improves considerably. This is demonstrated by faster transformation of carbohydrates, proteins and lipids, since organism burns off more calories per day.
For medical purposes these hormones are used for thyroid functioning abnormality and obesity (caused by this abnormality) treatment. Synthroid takes its action almost instantly like Cytomel. But Cytomel has another structure and is a synthetic hormone triiodothyronine (T-3). A sound man has enough quantity of both thyroid hormones in organism. But if we compare them, hormone T-3 is 4 times as stronger as T-4 (basically hormone T-4 takes its action after transformation of T-3).
Thyroid hormones are one of the most effective medicines for a sportsman. The intake of Synthroid causes a faster lipolytic digestion and rippling muscles. Since organism burns off more calories during the treatment course, diet becomes less important. This is especially important during competitions, since muscle bulk suffers when organism doesn’t acquire sufficient quantity of nutritional substances. The hormone intake will allow a sportsman to burn off lipids while consuming enough calories per day. Anabolic steroids are usually taken along with Synthroid in order to enhance growth of muscle bulk (proteins are better absorbed) due to increased metabolic activity.
Hormonal drugs for thyroid body always have a rick of metabolic activity change when they are taken in too big dosage or for a long time. A patient should be careful with dose titration and not take the drug for more than 6-8 weeks. For the same purpose, the dose should be gradually diminished at the end of the treatment course the same way it was increased at the beginning of therapy. The dose is recommended to be reduced by 25-50 µgr in 1 or 2 days. Organism gets used to the change in hormonal level and you’ll avoid ‘shock’ which is possible due to abrupt termination.
Synthroid may cause a number of side-effects, such as shiver, sweating, diarrhea, insomnia, vomit, arrhythmia, fatigue, or weight loss. In case the side-effects occur too often and become annoying, you should stop taking the medicine. Insignificant side-effects may be avoided if the daily dose is reduced.
To sum up, this TOP5 rating of popular medicines demonstrates a large variety of cutting-edge medications which are able not only to improve the quality of your life, but also to save it.