As a long-running safety tradition has it, you should be warned against any use of Viagra unless those specified by your doctor. In the manufacturer’s guide to Viagra you, too, will find a line that advises to take the drug for purposes indicated by the manual – or as indicated by your doctor. So what are these Viagra uses, apart from the obvious ED applications? It turns out, they are not so scarce. Read on to learn how beneficial this pill can be for patients suffering from a wide range of conditions associated with blood vessel constringency.

ViagraViagra’s main component, sildenafil citrate, is a potent vasodilator – and it is to this characteristic of the drug that all Viagra applications can be attributed to. In this section we will briefly survey little-known medical uses of Viagra which make the legendary blue diamond essentially multifunctional.

Viagra In ED Treatment

Since Viagra is first and foremost known as a male impotence pill, it is but natural to first speak about its application in ED therapy. Of this we have said a lot, and should you learn more about the role of Viagra in impotence treatment you can bounce off to the related section on this website. Here you will find the most basic facts underlying Viagra employment in ED therapy.

Sildenafil citrate is an antagonist of phosphodiesterase type 5, an enzyme that makes walls of blood vessels rigid and prevents cavernous bodies in the penis from absorbing blood. When sildenafil starts acting, it triggers the release of cGMP (cyclic guanosine monophosphate), a PDE5 antagonist. When blood vessel walls are thus decalcified, they become elastic and easily dilate to get filled with blood. Natural erectile mechanisms are thus activated, and maximal quantity of blood gets trapped in the penis until the moment of ejaculation.

For the purpose of ED treatment, sildenafil citrate is taken strictly as needed, to be more specific – an hour before sexual activity is anticipated. There is no need to stick to a particular posology pattern, but it is very important to follow the safety guidelines and never take more than one recommended dose of Viagra in 24 hours.

Viagra And PAH

As a matter of fact, it is with this use of Viagra that this section should have been started, since sildenafil citrate had been initially developed as a PAH solution. It wasn’t until the in vivo testing stage of drug’s development that the erectile-facilitating function of sildenafil was discovered as a secondary event. But it felt largely counter-intuitive to ignore the fact that Viagra is predominantly used as a drug against ED, so the PAH part comes only now. And so, here it is.

PAH, or pulmonary arterial hypertension, is a condition associated with pulmonary system dysfunction. PAH is a little known and rare disease that affects both men and women regardless of age and ethnicity. Even children can suffer from PAH. It has not been until this day exactly established why some people suffer from this disease. Pulmonary hypertension is high blood pressure in the pulmonary blood vessels, and is in itself not a disease but the result of some underlying problems, such as lung disease and / or hypoxemia (the body’s tissues are suffering a lack of oxygen) or chronic thromboembolism (blood clots).

Pulmonary arterial hypertension (PAH) is a form of pulmonary hypertension, which means that the pulmonary vascular changes and becomes too tight. What is happening and why is not entirely clear. When developing PAH is a change that allows pulmonary blood vessels to constrict and walls become thicker and less flexible. This makes the space inside the blood vessel smaller. With narrower blood vessels increases the resistance and the blood gets harder to reach the lungs.

Pulmonary arterial hypertension

Imagine a garden hose when pressing it together: less water comes out of the hose and the pressure in the hose will be higher. To begin with, compensates the heart’s right chamber of the growing resistance by working harder. It allows right ventricular muscle wall becomes thicker, the same way as other muscles (such as the shoulder muscle, biceps) becomes greater when they charged for longer. When the right ventricular muscle wall becomes thicker presses on the left side. This in turn makes the heart’s left ventricle may be more difficult to transport oxygenated blood to the body’s cells. In addition, can not take the right ventricle to pump as much blood as the body would actually need. As this process progresses, the amount of oxygen that reaches the body.

This state, with the lack of oxygen, causing PAH disease characteristic symptoms – shortness of breath and fatigue. The increased blood pressure in the pulmonary vascular irritate the artery walls and eventually leads to further vasoconstriction and wall thickening. This is the vicious circle started and the time increases blood pressure in the lungs’ blood vessels even more.

A number of different things happen in different body parts and systems of the body when you have PAH. The exact cause is still unknown, but what is known is that drastic changes including pulmonary vessels and the heart that they do not work normally. The inside of the blood vessels are composed of cells that are in direct contact with blood. In the pulmonary blood vessels close contact is necessary for the oxygen that you breathe in, will reach the blood flowing in the pulmonary vessels.

In PAH seen an imbalance of vasoconstrictor and vasodilator substances in the cell layer surrounding the blood vessels. In people with PAH, the concentration of an endogenous substance is observed called endothelin is abnormally high in the blood. The high concentration leads among other things to the small blood vessels in the lungs constrict. Elevated levels of the substance, thromboxane and decreased levels of nitric oxide and prostacyclin may also occur.

The most common symptoms are shortness of breath, fatigue, loss of condition (one feels “out of shape”), chest pain and / or feeling faint. The symptoms of PAH are usually divided into four so-called feature classes, based on the severity of symptoms the patient has and how severe the symptoms are. The disease develops gradually, so it may take some years before it is affected by PAH take symptoms seriously. The symptoms of PAH are often vague and easily confused with other heart and lung diseases such as left-sided heart disease, asthma and COPD (chronic obstructive pulmonary disease). Road to PAH diagnosis is neither easy nor obvious. Statistics show that more than three quarters of patients get their PAH diagnosis only when they have obvious symptoms.

Adults diagnosed for pulmonary arterial hypertension is usually treated by one of our university where specific PAH centers are available with expert knowledge of the disease. Knowledge of PAH and the potential to treat disease has increased significantly, but the disease can not yet be cured.

Two drugs in the family of PDE5 inhibitors, sildenafil and tadalafil, are used to treat PAH. Sildenafil (the one that is largely known as Viagra) is marketed under the trademark name of Revatio for filling in PAH subscriptions. The medicinal action of sildenafil is produced when the drug restores elasticity of the blood vessels and thereby addresses the problem. A posology pattern prescribed by a licensed healthcare provider should be followed when taking sildenafil for PAH treatment.

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Viagra In Multiple Sclerosis Effects

Multiple sclerosis, MS is a disease of the central nervous system, i.e. the brain and spinal cord. If you have MS occurs inflammation and scarring of the nerve fibers and it allows the impulse does not arrive as expected. Inflammation can be in different places in the central nervous system, and therefore may have trouble in different parts of the body. There are various forms of MS. Most often, the disease relapses, ie it comes in periods of discomfort. Over the years, patient can feel worse also between relapses. What symptoms you get and how long they last varies from person to person.

Multiple sclerosis

The disease is most common in women, and most people who get MS are aged 20 to 40 years. There is no known reason why people get the disease. There is no treatment that cures MS, but there are drugs that slow disease progression. Medicines come in form of solutions for injections, drip or tablets. If you become temporarily worse can be a short period to get treatment as cortisone. Rehabilitation, including physical therapy, is essential for mobility and quality of life.

A recent research carried out at Universitat Autònoma de Barcelona showed that Viagra can dramatically benefit multiple sclerosis treatment in animals: over 50% of models experienced major improvement in their condition. While the jury is still out on whether or not Viagra will become as successful a pill for multiple sclerosis as it is for ED, the possibility of it is given all due consideration and further researching is being carried out.

Viagra Benefits In Digital Ulcer (In Systemic Sclerosis Patients)

Systemic sclerosis or scleroderma is a complex disease that belong to the autoimmune system diseases. Systemic sclerosis is characterized by vascular involvement and fibrosis formation, which in addition to the skin may involve many other bodies. SSc is a rare disease with incidence numbers around 20 million cases per year. The disease can affect people of any age, but the onset is usually in middle age (between 30 and 50 years). As in many other rheumatic diseases, women are affected more often than men (3: 1).

Systemic sclerosis or scleroderma

Vascular symptoms are exhibited by virtually all patients with SSc (Raynaud’s phenomenon). In many cases, patients experience discharge in the affected area due to prolonged ischemia periods. Histologically one can in such cases show signs of severe intimal and adventitia fibros in digital arterioles. Overall, arterioles and arteries in patients with SSc exhibit both functional (i.e Raynaud’s phenomenon) and structural (obliteration secondary to fibrosis) changes.

This aspect of the disease had led French researches to consider possible benefits of sildenafil citrate in patients with SSc. Viagra used in individuals affected by digital ulcer significantly minimized the quantitative and qualitative parameters of ulcers during the course of 12 weeks in which the studies were carried out, providing ground for new Viagra applications. This effect of Viagra considerably improved the quality of life and hand function in patient with digital ulcer caused by SSc.

Article by My Canadian Pharmacy Experts