Generic Avodart (Dutasteride) at My Canadian Pharmacy: What Is Avodart For, Dosage, How Does Avodart Work, Contraindications and Side effects, Food And Drug Interactions, Avodart Vs. Flomax, Coupons
- What Is Avodart For
- Avodart Dosage
- How Does Avodart Work
- Contraindications: Is Generic Avodart Right For Me?
- Hair Loss Effects
- Possible Side Effects
- Food And Drug Interactions
- Safety Note On Generic Avodart
- Avodart Vs. Flomax (Dutasteride Vs. Tamsulosin)
- Avodart Coupons
What Is Avodart (Dutasteride) For
Dutasteride is an acting agent that inhibits 5-alpha-reductase in the two isoforms I and II. It has been approved as a drug for benign prostatic hyperplasia (increase in prostate volume). Avodart is used to treat symptoms of benign prostatic hyperplasia and reduce the relative risk of acute urinary retention.
Avodart is produced in form of soft capsules containing dutasteride 0.5 mg: the treatment of benign prostatic hyperplasia generally provides for a long-term therapy, since the therapeutic efficacy is observed only after about 6 months of treatment, characterized by taking one capsule daily by 0.5 mg of dutasteride. The capsule should be swallowed whole, because its contents may irritate the oropharyngeal mucosa. The entire treatment process should be supervised by your doctor.
How Does Avodart Work
Avodart is a drug based on dutasteride, active ingredient able to inhibit the two different isoforms of the enzyme testosterone 5-alpha reductase, an enzyme necessary to convert testosterone in its form at greater affinity for androgen receptors known as dihydrotestosterone.
The two isoforms, expressed especially in the skin (hair follicles and sebaceous glands), prostate and liver, responsible for this translation are critical during the development stages in ensuring the correct androgenic action to help determine the appearance and maintenance of the organs male genitalia and of the secondary characters.
However, the high concentration of androgens, combined with a progressive androgenic stimulation of the prostate, seems to be responsible for pathological conditions such as benign prostatic hyperplasia, for which the treatment with inhibitors of that enzyme, could be particularly effective in the regression of the symptomatology and in the reduction of prostate volume. Further studies are in progress to evaluate the effectiveness of this treatment to combat hair loss, which in part appears to be associated to an intense action androgen concentrated on the hair follicle.
Contraindications: Is Generic Avodart Right For Me?
Medicating with Avodart is contraindicated in patients with severe liver disease or a hypersensitivity to the active substance or to any of its excipients. Like finasteride, dutasteride may also inhibit the development of the external genitalia in the male fetus. Pregnant women should therefore avoid coming in contact with the drug. For lack of data, dutasteride is also contraindicated in patients with severe hepatic impairment.
Because dutasteride is also absorbed through the skin, all the people should not come in contact with the drug, i.e. women, children and adolescents, should not handle dutasteride capsules, more so if they are damaged. In case of accidental contact with damaged capsules occurred dutasteride, it is recommended to immediately wash the affected area with plenty of soap and water.
Avodart should be administered with care in patients with severe hepatic insufficiency, moderate or mild, because there are no specific studies on the effects of dutasteride on liver function, though it is known to be metabolized primarily by the liver. In vitro studies indicate that dutasteride is metabolized by the great family of the cytochrome P450 enzymes, specifically by CYP3A4 and CYP3A5 isoenzymes.
Avodart Generic Hair Loss Effects
Unlike finasteride and minoxidil topical, it has not been approved for the use in androgenetic alopecia. They were nevertheless carried out the trials (of scientific experiments on the use of a drug) by a pharmaceutical company known for its possible use in people with alopecia. Studies have shown that blockade of both isoforms of 5-AR has positive effects in the fight against androgenetic baldness while it is not yet determined the dosage (currently against prostatic hyperplasia is used the dose of 0.5 mg / day).
Possible Avodart Side Effects
All drugs can cause side effects, although these effects in most patients do not become apparent. Most adverse effects related to the administration of dutasteride pertain to the sexual function. Adverse effects were reported at a greater incidence during the first year of treatment; These effects were observed in higher rates for patients treated with dutasteride compared to those treated with placebo.
The most common side effects observed during the first year of treatment with dutasteride are: erectile dysfunction in approximately 6% of patients; decreased libido in about 3.5% of patients; decreased ejaculatory volume in about 1.8% of patients; breast enlargement in approximately 1.3% of patients. The incidence of such side effects has been decreasing during the second year of treatment, and practically impotence was observed in approximately 1.7% of patients, decreased libido in 0.6% of patients and decrease the volume ejaculatory in 0.5% of patients.
Other side effects that may occur during treatment with dutasteride include immune disorders, such as skin rash, itching, hives, swelling of the face, tongue and lips, and difficulty breathing.
Avodart Food And Drug Interactions
The metabolism of dutasteride is catalysed by CYP3A4 and CYP3A5. The enzyme CYP3A4 inhibitors (eg. ritonavir, indinavir, nefazodone, itraconazole, ketoconazole) may increase serum concentrations of dutasteride. You may need a reduction in dosing frequency in case of occurrence of side effects. In the case of enzyme inhibition, the long half-life can be further prolonged.
P-glycoprotein also plays an important role in the metabolism of dutasteride. All this is confirmed by a pharmacokinetic study, where a small group of patients treated with dutasteride were co-administered verapamil or diltiazem, both inhibitors of CYP3A4 and P-glycoprotein; after administration of such drugs, the plasma concentration of dutasteride was found to be 1.5 to 2 times higher than normal.
Safety Note On Avodart
Avodart administration should be preceded by a careful medical examination useful to exclude the possible presence of prostate carcinomas, for which a different therapy would be indicated. At the same time, it is useful to remember that dutasteride significantly decrease plasma concentrations of PSA, could therefore distort the reliability of this diagnostic marker.
During treatment routine medical checkups are necessary, used to evaluate the therapeutic efficacy and to exclude the possible occurrence of neoplastic foci.
Avodart is indicated for the exclusive treatment of male disease, therefore it is contraindicated in women, particularly during the pregnancy and in children because of the possibility of altering the proper development of the external genital organs and secondary sexual characteristics.
Before starting the treatment of benign prostatic hyperplasia with dutasteride, it is recommended to perform an accurate patient monitoring, in order to rule that the symptoms reported were related to prostate cancer; in particular, before starting treatment – and also as a precaution during treatment – it is recommended that both the digital rectal examination of the prostate, is the determination of prostate specific antigen (PSA).
The prostate specific antigen plasma concentration is in fact an important tool to detect the presence or absence of prostate cancer. If the plasma concentration of PSA is greater than 4 ng / ml, it is recommended to investigate further and possibly a biopsy of the prostate; this level may in fact indicate the presence of a prostate cancer.
A very important thing to remember is that dutasteride helps to lower prostate specific antigen plasma levels by approximately 50% after the first six months of treatment, so physicians should be cautious in the periodic checks of the prostate of individuals treated with dutasteride , since a low prostate specific antigen level at times it does not exclude the presence of prostate cancer. Therefore, to correctly interpret the values of PSA in patients treated with dutasteride for more than six months, it is important to multiply by two the detected values; in this way you will obtain the actual plasma levels of PSA maintaining the sensitivity, the ability and specificity of the assay for the detection of prostate cancer. Serum PSA levels tend to normalize within six months of discontinuing treatment with dutasteride.
Before starting treatment with dutasteride it is also recommended to exclude the possibility of an obstruction of the prostate due to growth of lobular type thereof.
Avodart Vs. Flomax (Dutasteride Vs. Tamsulosin)
Avodart is a new generation drug with an improved formula compared to that of Flomax (tamsulosin). The use of this innovative dual inhibitor of 5 alpha reductase has proven effective in reducing prostate volume in the course of benign prostatic hyperplasia, the rate of acute urinary retention and the need for surgical intervention. However, Flomax remains to be the first-line treatment for prostate diseases.
The two drugs serve different purposes. Avodart removes the urge to urinate frequently, while Flomax addresses the problem of painful urination. Rather than choosing between the two drugs, prescribers often appoint a combination therapy for optimized health outcomes.
Combination therapy with tamsulosin appears to be more effective than only one dutasteride in men with prostate volume increased from 30 to 58 ml. These advantages are lost more thrust benign prostatic hyperplasia.
Generic Avodart Coupons
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