Cialis Black 800mg (Tadalafil) at My Canadian Pharmacy: Definition, Applications, How To Use, Contraindications and Side Effects, Health Effects And Benefits, Food And Drug Interactions, Safety Note

Cialis Black 800
5.0 of 5.0 based on 1 votes
Product name Cialis Black 800
Price

from 4.95$ to 4.01$

Category Erectile Dysfunction, Men's Health
Active ingredient Tadalafil
Avaliability In Stock
Dosages
800mg
Quantity
30 pills 60 pills 90 pills

CONTENT


Cialis Black 800mg (Tadalafil Generic) Definition

Cialis Black ApplicationsGeneric Cialis Black 800mg is a drug indicated for the use in males with severely compromised erectile function. Cialis Black features a maximally enhanced formula that encompasses both a chemically active ingredient tadalafil used in the original Cialis, and time-tested herbal ingredients that provide additional benefits in health outcomes. Cialis Black improves sexual performance by increasing endurance, stamina and amplifying libido. This is achieved thanks to the presence of natural herbal aphrodisiacs in the drug’s composition.

Thanks to the presence of herbal components that intensify the sex drive, Cialis Black is especially beneficial for individuals with decreased libido and those in whom erectile difficulty is conditioned by psychological reasons and internal blocks associated with weak sexual constitution. Such lack of sexual desire can be linked to congenital or acquired physical and mental diseases (hormonal changes, psychological blocks, severe stress etc.).

Generic Black Cialis Applications

Cialis Black is used to treat erectile dysfunction (ED) in its advanced stages (which is defined as complete inability to achieve penile hardness for an intravaginal penetration), aggravated by a decrease in libido and / or stamina. The herbs used in Cialis Black revive sexual energy and stimulate sexual desire, unlike the conventional pills that only contain tadalafil as the main and the only medicinal ingredient.

Its unique composition renders Cialis Black an exclusive status of a sex health pill with a special libido-boosting status. The drug’s advantages are reinforced by a safe combination of ingredients that jointly provide erectile and sensual intensification. Cialis Black is purposefully developed to benefit patients who require an improving agent for the sexual ability as well as the capacity.

The utility of Cialis Black lies with the medication’s proven safety, whereas combining herbal and othe existing aphrodisiacs with pharmaceutical drugs for erectile function always poses risks of adverse reactions linked to pharmacological incompatibility.

Thanks to this unprecedented combination, Cialis Black 800mg effectively addresses psychological ED, which otherwise displays a lower percent of curability.  This is why Cialis Black addresses a broader spectrum of ED cases than the original tadalafil pills that appear to be effective both organic impotence rather than psychogenic.

How To Use Cialis Black

The drug can be taken “as needed” from 30 minutes to 12 hours before sexual activity. The recommended dose is one tabled. Do not increase the dose in the case of ineffectiveness, since Cialis Black contains the maximal dose of tadalafil allowed for ingestion within 24 hours’ timespan.

Contraindications: Is Cialis Black Right For Me?

Speaking on the metabolic cycle NO / cGMP, tadalafil potentiates the hypotensive effect of nitrates and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation. It is also contraindicated in patients with a recent history of stroke and heart attack, and for possible disturbances to vision, even in patients with degenerative retinal diseases such as retinitis pigmentosa. The drug should not be used in patients with severe hepatic impairment.

Cialis Black Health Effects And Benefits

Cialis Black Health Effects And BenefitsTadalafil is the second reversible selective inhibitor of phosphodiesterase type 5. The phosphodiesterase (PDE) are a group of enzymes involved in numerous cellular functions. The PDE5 is present in high concentration in the smooth muscles of the corpus spongiosum of the penis where the enzyme promotes the degradation of cyclic guanosine monophosphate (cGMP). The increase in cGMP leads to a relaxation of the smooth muscle cells – vasodilation – which allows an increase of blood flow in the cavernous bodies of the penis, is the basis of the mechanism of erection.

The physiological mechanism of erection, after sexual stimulation, is mediated by the release of nitric oxide (NO) at the level of the corpus spongiosum by postsynaptic parasympathetic neurons and, to a lesser extent, by endothelial cells; the nitrogen oxide rapidly diffuses and stimulates the guanylate cyclase in smooth muscle cells that surround the sinusoids of the corpus spongiosum, increasing the cGMP content that causes their relaxation.

Tadalafil potentiates the action of cGMP, which is the reason why its effectiveness is manifested only when, as a result of sexual arousal, the central type or reflection, increases the production of cGMP in penile tissues: then its operation is subordinate to the integrity sexual interest, with the whole cascade of biochemical events that are interrelated. The participation of the partners to the sexual act is becoming a determining factor. If there is no excitement and emotional engagement, the drug has no effect. Tadalafil does not increase the frequency and intensity of sexual desire.

Tadalafil has a different chemical structure from sildenafil and, unlike the latter, in vitro shows poor activity against other PDE isoforms, as PDE6 present in the retina.

After oral administration, reaching peak plasma concentrations after about two hours, it is metabolized by cytochrome P450 and is eliminated as inactive metabolites mainly in the faeces and to a lesser extent in the urine. The kinetic profile of tadalafil differs from that of sildenafil especially for the longer half-life, 17.5 hours vs. 3.8 hours. Consequently the onset of action is delayed compared to sildenafil but much more protracted. Studies show significant activity even 24 hours after taking the drug.

Possible Cialis Black  Side Effects

Side effects of tadalafil are similar to those of sildenafil: the most frequently reported during the studies were, in descending order, headache, indigestion, back pain, myalgia, flushing of the face, nasal congestion, diarrhea. At the moment the data are insufficient to assess the long-term side effects, and in groups of patients at high cardiovascular risk.

Headache, flushing and dyspepsia are closely related to the mechanism of pharmacological inhibition of type 5 phosphodiesterase isoenzyme. This fact is not only in the corpus spongiosum, although predominant here, and be effective also in other metabolic pathways . The tadalafil, thanks to the greater selectivity for PDE5 with respect to PDE6 (found in high concentration in the retinal cells), seems to cause less easily, compared to the sildenafil, vision abnormalities.

Like other inhibitors of PDE5, tadalafil also has the potential of lowering your blood pressure, which could be a problem in patients being treated with antihypertensives.

During postmarketing surveillance, they have come to the US and Canadian health authorities some reports of non-arteritic anterior ischemic optic neuropathy (NAION) occurred in patients taking inhibitors of phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction. The NAION is due to a lack of blood flow to the optic nerve and results in a sudden loss, painless, partial or complete, of the view, in one or both eyes. Although some patients may have a functional recovery over time, in others the damage is irreversible. Patients who have had an episode of NAION are at greater risk of experiencing a second episode in the other eye.

Among the factors predisposing to the onset of NAION there are included:

  • age older than 50 years
  • the presence of coronary artery disease
  • a high pressure
  • high cholesterol
  • diabetes
  • smoking

These risk factors play an important role in the onset of erectile dysfunction.

Most of the reports of NAION associated with the use of PDE5 inhibitors sildenafil concerns (38 of the 43 cases reported to the FDA and 2 were reports to the Canadian authorities) and, respectively, 4 recommendations are related to tadalafil and vardenafil. The majority of patients had one or more of vascular risk factors for NAION.

The small number of reported events compared to the large number of users of PDE5 inhibitors and the fact that most of the reports concern patients with a risk profile similar to patients diagnosed with NAION but that does not make use of these drugs, make it difficult at the time, with security to establish a causal link between the use of PDE5 inhibitors and the appearance of this disorder. However, some factors, such as the temporal causality between the drug and the onset of NAION in some of the reported cases and the presence of recurrent ocular symptoms consistent with NAION in other cases, make this plausible association.

Looking forward to better define the safety of use of PDE5 inhibitors, health authorities recommend to:

  • Advise patients to immediately stop taking Cialis Black if there were to be a sudden reduction of vision in one or both eyes, and immediately report the event;
  • Discuss with patients who have a history of NAION the possible increased risk of optic neuropathy associated with the use of these drugs and to evaluate with them the opportunity to use.

Cialis Black Food And Drug Interactions

It is possible for Cialis Black to have interactions with any drug inducer or inhibitor of CYP3A4. There are no interactions with food and alcohol. Cialis Black should not be taken simultaneously with anti-hypertensive drugs and chest pain (angina) drugs that contain nitrates. Drugs that have blood-lowering pressure as a side effect should not be used alongside with Cialis Black, since such effects will be reinforced in an uncontrolled manner by the hypotensive action of tadalafil.

Safety Note On Cialis Black

Speaking on the metabolic cycle NO / cGMP, tadalafil potentiates the hypotensive effect of nitrates and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation.

Patients with known allergies should report them to their prescriber before proceeding with Cialis Black therapy.

Cialis Black contains a maximal dose of tadalafil, which makes its use contraindicated in patients with liver, kidney, stomach and heart problems, as well as persons belonging to the geriatric group of patients.

Generic Cialis Black 800mg by My Canadian Pharmacy Specialists – www.mycanadianpharmacyrx.com