My Canadian Pharmacy Review: Sildenafil Citrate (PDE5) and Its Stand in Modern Pharmacology
Even though you haven’t heard of Sildenafil Citrate, you are surely aware of many products that contain it: today these are mainly ED medications sold under numerous trade names. Being the major component of impotence pills, Sildenafil works increasing the blood flow, allowing men worldwide enjoy harder and longer erection. But this encyclopedia line says a little about the element, and you surely have to learn a lot more.
From the History of Sildenafil Citrate
Sildenafil Citrate Work Sildenafil was initially discovered by the British scientists. However, their primary initiative was far from finding the cure for erectile dysfunction in males. The element was found to treat high blood pressure (hypertension) as well as the ischemic heart diseases’ symptoms (angina pectoris).
They hoped for excellent results, yet during multiple tests and trials things appeared to be quite different. The first results have established that Sildenafil Citrate had a little influence on angina or hypertension treatment. At the same time it affected penile erection, improved it and made it last for a long time. This is how a forefather of all modern ED medications was discovered.
After a surprising discovery the scientists decided to continue using Sildenafil for impotence treatment. In 1996 the drug was firstly patented in the USA. It entered the market two years later in 1998 after it got the FDA approval.
! This is how, purely by accident, the world got the medication that can treat erectile dysfunction of different categories and difficulty levels.
How, When and Where Does Sildenafil Citrate Work?
Do you know that the human body is the home for 11 types of phosphodiesterase? Half of them were discovered in 1997. Many of them are found in the penile area (2,3,4,5), but PDE5 is the predominant one.
How does Sildenafil Citrate work? The active ingredient works as a competitive inhibitor of phosphodiesterase type 5-class. When there’s sexual stimulation the neurotransmitter or NO is released across numerous neuromuscular junctions of both the cavernosal smooth muscles as well as the penile arteries. NO triggers the increase in the cGMP release (molecule cyclic guanosine monophosphate). The latter one leads to penile smooth muscle relaxation. It also creates:
- increased blood flow;
- cavernosal smooth muscle relaxation;
- penile rigidity and tumescence.
At this time the inhibitor breaks down the cGMP and results in penile arteries contraction. Anything that can possibly affect cGMP by increasing its production or by preventing its breakdown will have an effect on the erectile function.
What is the chemical structure of Sildenafil Citrate? The chemical structure of the element is similar to that of cGMP. Sildenafil Citrate binds to the PDE-5 enzyme. It prevents the breakdown of cGMP by means of a competitive inhibition.
It’s obvious that many health conditions and other factors are associated with the process. Their list includes:
Most of these diseases are associated with the decrease of endothelial levels of NOS (it is the nitric oxide synthase). NOS is the enzyme, which produces NO. And when the synthesis of NO is diminished, it may lead to NO decrease as well as the low efficacy of cGMP muscle relaxation. Sildenafil is an active element that assists in coping with any of the tough cases.
! When the ED condition occurs due to neuronal loss (the after non-sparing radical prostatectomy case) or the patient is suffering from really severe arterial diseases, Sildenafil is not effective. This is especially true if the arterial disease is characterized by the fixed vasculopathy and the latter one prevents any arterial smooth muscle relaxation.
In case of oral administration Sildenafil is quickly absorbed in the small intestine. The time required to peak sildenafil concentration in plasma is from half an hour to 2 hours. If there’s something that can delay gastric emptying, it will definitely delay the time to peak its concentration in plasma. As a rule, a negative effect is provided by a high-fat meal that delays the effect by 60 minutes as well as reduces plasma concentration by nearly 29%.
! What about the peak efficacy? It is seen if Sildenafil is taken on an empty stomach (the observed clinical efficacy equals 19 minutes).
Sildenafil Citrate is metabolized by 3A4, 2C9 or P-450. Erythromycin, along with cimetidine, ketoconazole or any other inhibitor of these enzymes will delay metabolism and will require dose adjustments. However, the latest trials showed that men concomitantly taking P-450 inhibitors experienced no delays or adverse reactions.
How to make this Canadian Pharmacy medication safe? Its safety is established in doses. The maximum recommended dose is 100 mg. Patients shouldn’t take doses that are greater than 25 mg, in case there is the presence of the protease inhibitor ritonavir. Why? The fact is that it shares metabolic ways with Sildenafil. The action duration lasts for nearly 3 half-lives, yet there are men who experience stunning effects during 24 hours.
Sildenafil Citrate in Modern Pharmacology
In modern pharmacology this active element is represented by two medication types: Revatio and Viagra.
Revatio inhibits cGMP PDE5 in the pulmonary vasculature smooth muscle, because this is where PDE5 is responsible for cGMP degradation. It increases cGMP within the smooth muscles of the pulmonary vessels, resulting in muscle relaxation. This is how Revatio saves people with pulmonary hypertension.
Viagra is able to enhance the effects of nitric oxide by inhibiting PDE5 (phosphodiesterase type 5) on the penile corpus cavernosum. The effect is both the vasodilation and increase blood flow to the corpus cavernosum. When there is sexual stimulation, great penile erections are guaranteed.
Sildenafil Citrate as Viagra’s Main Component
When in 1998 Sildenafil Citrate was marketed as Viagra and received its FDA approval, it became the first medication to treat erectile dysfunction in men. It was initially prescribed for more than 10,000,000 men around the globe. It gained popularity in the USA, EU, Canada, etc. Today anyone can order the medication from Canadian Pharmacy online and enjoy drug’s excellent effects on his sexual life.
Generic Viagra pills www.mycanadianpharmacyrx.com/generic-viagra-sildenafil are becoming more popular than brand ones. Their recommended dose is 50 mg. If a male responds to this amount adequately, the dose can either be decreased to 25 mg or increased to 100 mg, depending on doctor’s prescription. When Sildenafil Citrate is taken about 60 minutes before sex, it will remain in the body during 4-5 hours.
Unfortunately, the drug is not able to increase male’s sexual desire. If one wants the medication to become the most effective in his case, he should think of proper sexual stimulation. Don’t mix it up with aphrodisiacs: Viagra is widely used as a recreational drug, yet there isn’t any clinical evidence that prove that its single Sildenafil-containing pill can improve sexual performance in men, who aren’t suffering from impotence.
! The usual question that interests men worldwide is whether there are coverage and insurance plans for Sildenafil Citrate. In 1999 a health insurance consulting group indicated that millions of men take Viagra at least once a week, so it means that they can receive a kind of insurance reimbursement for this drug. A single pill costs about $10, so the insurers can limit the coverage to a specified number of pills per month.
What Canadian Viagra Pills Include Sildenafil Citrate?
Canadian Viagra at www.mycanadianpharmacyrx.com is available in different sizes, shapes and types. What for? The variety of drug’s forms and shapes allows choosing what one really need, switch from one medication to another, reduce side effects or improve erections. Depending on the ever-changing circumstances of a man’s life, he has a chance to order and get just what is proper for him.
Classic Generic Viagra
It comes in doses of 25 mg, 50 mg and 100 mg. All the pills contain Sildenafil Citrate that helps to restore man’s sexual power via simple and clear mechanisms. As the doses are different, so are their pharmacological forms, continuity of action, etc.
This medication can be ordered from Canadian Pharmacy as well. Its characteristics are slightly different from those offered by classic pills. Viagra Professional or PRO, as it is frequently referred, features an enhanced Sildenafil Citrate formula and is characterized by an increased content of its main component. The drug’s efficacy is excellent! It is the optimal medication for men with really severe cases of erectile dysfunction.
Viagra Super Active
It’s a popular generic Sildenafil product with a so-called power-packed formula. Viagra Super Active promotes sexual stamina, allows enjoying sexual recharges more often, and causes fewer side effects. While taking such pills, men don’t have to get worried about their performance.
Viagra Black, Viagra Red and Viagra Super Force
All these drugs are very close in their characteristics. They contain Sildenafil Citrate as well. Unlike other pills, they don’t only help men with ED problems, yet also provide some bonus powers for a great measure.
! Those, who are eager to rock within 15 minutes after the intake, should order such Viagra types as Viagra Lozenges, Softabs, Thin-Film, Jelly or Viagra Capsules. They are dissolved in the mouth and get into the bloodstream faster than Sildenafil Citrate from ordinary tablets.
Generic Viagra at My Canadian Pharmacy
Why choose us? We offer the best choice & prices from all Canadian Pharmacies online! There are many different reasons why patients pick online services instead of regular local drugstores. While choosing a reliable source, patients get much more than just high quality pills. They also enjoy:
- quality services;
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The high quality of service is the first thing a customer experiences while shopping from Canadian Pharmacy. A reliable pharmacy provides customer support online, accurate and efficient delivering, easy and smooth ordering process, etc. In fact, there are much more other departments that clients don’t see.
What does secure shopping include? The first and foremost position is taken by the safety of personal info, health facts and payment details (private data). The service is protected using SSL encryption of 128 bit or even higher. The website address is preceded by https://, plus there’s a padlock sign placed somewhere in the visibility for clients to see that their information will remain private.
Anonymity takes a huge part in the process of purchasing from Canadian Pharmacy. Though it comes very close to the shopping securing, it still extends beyond it. Considerate billing statement and discreet packaging are a must! In addition to this, a professional pharmacy never uses a spamming approach.
And finally, there is no better way to express care as well as gratitude towards new customers or old-timers than to offer discounts, bonuses, loyalty rewards or special prices. We offer you the best choice of medications and costs from Canadian Pharmacy.
The present day offers many active elements and ingredients that can change one’s life for better. Now that you know what role is taken by Sildenafil Citrate, you need to decide where to get it from. Quality generic pills cost less than their band counterparts. Search for online pharmacies with reliable reputations and positive customer feedback, low prices and pills that aren’t provided by Indian or Pakistani manufacturers. Get to know and learn more from the tips and info provided by My Canadian Pharmacy www.mycanadianpharmacyrx.com. Make all Sildenafil Citrate’s positive features and aspects work for your benefit!