Silagra (Generic Viagra / Sildenafil) at Canadian Pharmacy: Definition, Applications, How To Take, Silagra Vs. Kamagra, Contraindications and Side Effects, Health Effects And Benefits, Food And Drug Interactions, Safety Note
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- Silagra Definition
- Silagra 100mg Applications
- How To Take Silagra 100mg
- Silagra Vs. Kamagra And Other ED Drugs
- Contraindications: Is Silagra Right For Me?
- Health Effects And Benefits
- Possible Silagra Side Effects
- Food And Drug Interactions
- Safety Note On Silagra
Silagra (Generic Viagra/Sildenafil) Definition
Silagra (sildenafil) is an oral drug used to temporarily remove erectile dysfunction (ED) symptoms and allow an individual suffering from impotence to perform sexually. The drug allows to achieve and maintain penile erection of a hardness and stability that are sufficient for the completion of a healthy sexual act.
Silagra 100mg Applications
Silagra is used for the treatment of erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual activity. Sexual stimulation is required directly before the sexual act for sildenafil to be effective. the use of sildenafil is not indicated in women.
Erectile dysfunction is a common problem; the estimates are rather difficult, however, and on the low side: it seems that only 5-10% of men suffering from impotence consult their doctor. Considering all ages, it seems reasonable to believe that it is suffering at least 1 man in 10 advancing age the frequency increases to affect about 65% of men over 70 years. Contrary to the findings before the 90s, in most cases, impotence has organic and not psychological causes.
Conditions that can lead to erectile dysfunction are the endocrine and vascular diseases such as diabetes, chronic heart disease, hypogonadism, the interventions of removal of the prostate, neurological and psychiatric disorders, stress, anxiety and depression. The causes can be pharmacologic. The possible surgical treatments (penile prostheses), accompanied by effective drug treatments and less traumatic: intracavernous alprostadil for injection and glow plugs for intraurethral administration and inhibitors of PDE5, of which sildenafil contained in Silagra is the basic solution.
How To Take Silagra 100mg
Silagra has an elevated sildenafil content (sildenafil 100mg). The recommended dose for most patients is sildenafil 50mg 1 hour before sexual intercourse: however, in the case of ineffectiveness, the dosage can be increased to 100mg if tolerated. In some patients 25mg may be sufficient. The drug should not be taken more than once a day.
Silagra Vs. Kamagra And Other ED Drugs
Silagra is identical to Kamagra in its uses, effects, safety and administration route. Just like Kamagra, Silagra is a generic version of Viagra, which explains such complete convergence of the three ED agents.
In addition to the route of administration, PDE5 inhibitors, as compared to alprostadil, a major difference: they enhance the action of cGMP, the effect manifests itself only when, as a result of sexual arousal, central or reflex type, increases the production of cGMP in penile tissues. Sildenafil and congeners are able to manifest their action only when it is still intact sexual interest, with the whole cascade of biochemical events related. If there is excitement and emotional engagement, the drugs, the recommended doses are ineffective. Sildenafil appears to be effective both organic impotence that in the psychological.
A recent systematic review evaluated the efficacy of sildenafil in the treatment of erectile dysfunction. The review included 27 studies, totaling 6,659 patients. The use of sildenafil produced a significant improvement in erectile function compared to placebo in all studies examined. The primary outcome measure was represented by the percentage of sexual intercourse that patients were able to complete successfully. Secondary outcome measures were: the number of patients who were able to get at least one sexual relationship in the last 4 weeks before the end of the study and improvement of erection capacity. In all included studies, the evaluation was carried out through the answers to a questionnaire completed by patients at the end of the study. With regard to the primary outcome measure, the efficacy of sildenafil was higher with higher doses between those employed (25-100mg), while there was no difference between the different dosages with respect to the number of patients who managed to have at least one sexual relationship in the last 4 weeks before the end of the study.
Studies with alprostadil and sildenafil are not directly comparable because of differences in the enrolled subjects, the criteria for evaluating the effectiveness and duration of treatments.
Silagra Contraindications: Is Silagra Right For Me?
As a result of its mechanism of action that works on the metabolic cycle NO / cGMP, sildenafil potentiates the hypotensive effects of nitrates, and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation.
Despite several parts if it is assumed to possible use in the woman, for a suppository similarity in the mechanisms of clitoral erection, are not available to date data to that effect.
Silagra contains 100mg of sildenafil, which is the maximal recommended dose. Persons with increased sensitivity towards sildenafil should not take Silagra. It is always better to start treatment with sildenafil from the lowest doses (sildenafil 25mg) and gradually work it up until the minimal effective dose is established.
Silagra Health Effects And Benefits
Following sexual stimulation, the physiological mechanism of erection is mediated by the release of nitric oxide (NO), at the level of the corpus spongiosum, by postsynaptic parasympathetic neurons and, to a lesser extent, by endothelial cells; simultaneously it takes place a block of adrenergic neurons in the smooth muscles of arteries and cavernous trabeculae. The nitrous oxide rapidly diffuses and stimulates the guanylate cyclase in smooth muscle cells surrounding the sinusoids cavernosa increasing the cyclic guanosine monophosphate content (cGMP) which causes their relaxation. Sildenafil inhibits phosphodiesterase type 5 (PDE5), the enzyme responsible for degradation of cGMP levels in the corpus spongiosum. The increase of cGMP levels results in a relaxation of the smooth muscle cell which allows an increase of blood flow in the cavernous bodies of the penis.
Nitric oxide is also formed at other peripheral nerves and in other endothelial cells, in the brain and in platelets. In these tissues the activation of guanylate-cyclase results in vasodilation, increased synaptic transmission, adhesiveness, and inhibition of platelet aggregation. At the level of these tissues sildenafil it could therefore have very different effects. This event has not occurred in studies, at least those in which the drug was taken in non-continuous way to improve erectile function.
Orally administered, Siilagra is rapidly absorbed with a bioavailability of 40%. Maximum plasma concentrations are reached on average after 60 minutes. It is metabolized via the liver to an active metabolite with properties similar accounting for about 20% of total activity. The metabolism is primarily mediated by cytochrome P450 (isozymes 3A4 and 2C9): inhibitors of this enzyme (eg. Cimetidine) may reduce sildenafil clearance. The drug has a mean half-life of 3-5 hours.
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Possible Silagra Side Effects
Sildenafil appears to be well tolerated overall. The most common side effects reported during the studies were, in descending order, headache, flushing of the face (by vasodilation), dyspepsia, diarrhea, nasal congestion, and body aches. They also expressed, especially with higher doses, temporary changes in vision (discrimination of blue / green color, light sensitivity, blurred vision and bluish) that reached their climax in conjunction peak plasma and dragged on up to 5 hours .
Headache, flushing and dyspepsia are closely related to the mechanism of pharmacological inhibition of type 5 phosphodiesterase isoenzyme. This fact is not only in the corpus cavernosum, although predominant here, and be effective also in other metabolic pathways . Moreover, despite the in vitro studies indicate a high specificity for sildenafil for the type 5 phosphodiesterase, this specificity is reduced against phosphodiesterase type 6 present at the level of the retina and are attributable to this the effects on vision. They were reported rashes and priapism.
During the post-marketing surveillance several neurological disorders have emerged associated with the use of the drug. They include: confusion, dizziness, anxiety, agitation, aggression, euphoria, hallucinations. One possible explanation is that the drug, after crossing the blood brain barrier, go to interact with the PDE type 5 present in the brain, particularly in the areas that govern the emotional sphere, and sexual behavior.
Silagra Food And Drug Interactions
Sildenafil in the content of Silagra is metabolized primarily by CYP3A4 and to a lesser extent by CYP2C9 therefore it is possible that inhibitors and inducers of these isoenzymes 2 interfere with the kinetics of the drug. Co-administration with erythromycin causes an increase in sildenafil plasma levels of approximately 3 times. Therefore, as a precaution, it is necessary to reduce the dosage of sildenafil in case the patient should take this antibiotic. And ‘likely that other potent enzyme inhibitors such as ketoconazole and itraconazole cause a similar effect.
Taking sildenafil in combination with the protease inhibitors indinavir, ritonavir and saquinavir causes a marked increase of its serum levels. The increase was greater with ritonavir. According to reports in the Italian data sheet of Viagra specialties, co-administration with this drug is contraindicated. When combined with indinavir and saquinavir, the recommendation is to initially administer the lowest dose of sildenafil (25mg) before increasing the dose to Silagra 100mg.
Safety Note On Silagra
Silagra has not been evaluated in combination with other drugs currently used to treat impotence that associations of this type should be avoided. It is not known whether the drug can induce permanent changes in vision and, according to some eye doctors, it is necessary to undertake long-term studies to verify this aspect, suggesting that, in the meantime, the drug should be used with caution by patients suffering from retinal problems. Patients at increased cardiovascular risk should be informed of the risks linked to an “unconditional resumption” of sexual activity.