My Canadian Pharmacy is Giving Away Free Extra Pills of Generic Viagra and Cialis

Erectile dysfunction treatment can be tough, and not only psychologically. To make sure you are on the right way to recovery you must cut off a tangible part of your paycheck to maintain the optimal treatment course. My Canadian Pharmacy is making a huge contribution into keeping the price range for ED drugs at an acceptable level, but now it is on the verge of another breakthrough. Now you can take advantage of an extra load of Generic Cialis or Generic Viagra samples with your order for no cost. Treating erectile dysfunction is a very individual process, so trying on a variety of pills is rather a necessity than just a plausible treatment enhancement. Now at Online Canadian Pharmacy you not only save money with affordable, top quality generic meds, but also diversify your treatment for no cost, make it more targeted and efficient.

Full information about Generic Viagra and Cialis – You Can Find in this Articles:

Generic Viagra: Drug information

Generic Cialis: Uses, Side Effects, Interactions, Dosage

Viagra and Cialis – Cracking Down Your ED issues at a Juicy Price

My Canadian Pharmacy is Giving Away Free Extra Pills of Generic Viagra

Erectile dysfunction refers to inability to achieve and/or maintain an erection that is enough to have a satisfactory sexual intercourse. The prevalence of ED problems varies depending on the patient’s age: while in 20 – 40 yo age group its frequency varies in 5 – 8% range, 40 to 60 years old men are way more likely to have these problems as ED occurs in 15 – 25% of cases. At 65+ years the ED issues paralyze sexual abilities of 35%  – 55% of men. Erectile dysfunction is primarily caused by psychogenic and somatic reasons, and the term ED is never considered to be a standalone disease – in the overwhelming number of cases the problems are caused by more serious underlying issues. That’s why in the event of recurring sexual problems a comprehensive health examination is appointed.

A huge number of clinical trials and tests in the last 2 decades have confirmed that erectile dysfunction is quite rarely caused by psychological reasons, while around 80% of erectile dysfunction cases are triggered by physical conditions. These include diabetes, high blood pressure, high blood cholesterol and atherosclerosis, kidney and liver failure, thyroid disease, hormonal disorders, the effects of operations on the prostate and the rectum, trauma, spinal and brain diseases, the effects of pelvic injury, Peyronie’s disease (learn more) and others. Erectile dysfunction can also be provoked as a result of taking certain medications. Persistent erectile dysfunction can develop as a result of unhealthy habits like drinking, smoking and drug use.

In the process of time patent protection of costly branded medications expires, and from that moment generic drugs evolve – this is the way Generic Cialis and Viagra were born. Generic drugs are essentially the copies of original meds, but cheaper because producers are exempted from spending money on formula development and gigantic marketing expenses. Generic manufacturers work with a ready medicinal product and have no need to prove its safety and effectiveness in large studies. However, the requirements for the production of the generic and original and are virtually the same. Generic drugs are due to be manufactured in accordance with GMP requirements and meet bioequivalence levels – in short a therapeutic equivalence.

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How it Works

cGMP

To understand how the drug acting directly on the smooth muscle of the penis is produce, you should study the mechanism of blood circulation in our body. There’s only one pump in your body – the heart; however, different organs require certain amounts of blood to be delivered simultaneously. For example, when running a long distance, your body supplies your arms and legs muscles with more blood, and causes a reduction in the amount of blood flowing, for example, to the stomach (and other less intensively used areas) in order to preserve oxygen.

The mechanism of blood circulation has the following chemical nature: your brain sends signals through nerve fibers that  reaches nerve cells in the areas where the blood flow adjustments is required. These nerve cells (non-adrenergic, non-cholinergic) produce nitric oxide (more in Wiki), which enters the bloodstream and the surrounding cells. Nitric oxide promotes the development of guanylate cyclase enzyme, which in turn promotes the creation of a substance – cyclic guanosine monophosphate (also known as cGMP); under the influence of the cGMP smooth muscles that line the wall of the arteries relax, lead to increased blood flow. Another enzyme – phosphodiesterase, or PDE, ceases the action of cGMP. It turns out that cGMP acts as the brain sends signals. Once the brain ceases to send them, the effect of cGMP is terminated because the process is closely interconnected with PDE production.

Creation of the drug that aims at increasing blood flow to genitalia, one of the following ways can be turned into account:

  1. nitric oxide production increase;
  2. cGMP level increase;
  3. PDE level reduction to facilitate cGMP accumulation instead of its disintegrating.

Generic Viagra creators decided to choose the third way – to eliminate phosphodiesterase, the accumulation of which results in the breakdown of cGMP. The smaller the content of PDE, the greater cGMP content would be, and the greater blood flow and the stronger erection will follow. The mechanism of Cialis is identical.

The reason for choosing this particular is explained by the number of types of phosphodiesterase in the human body – which only have 11 species. And PDE-5 is the only one found in male genitalia. Once the researchers discovered this fact, the commercial release of Viagra was just a matter of time, because since then the challenge was limited to finding a chemical capable of selectively blocking PDE5. So with the introduction of the drug blocking PDE5, cGMP begins to accumulate in the penis, and blood flow there is enhanced without affecting other systems of the body.

In the event of the absence of significant issues caused by physical traumas, Generic Viagra and Cialis demonstrate impressive treatment results ranging from 64% to 78% success rate in Generic Viagra and 69% – 85% in Generic Cialis. These results are based on the series of 4 – 8 week studies that included placebo groups, the success rates at which varied in 17 – 24% range.

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On top of all the advantages now you can upgrade your order with a free 4 pills blister of Generic Viagra or Generic Cialis to explore the benefits of both drugs, evaluate their impact and make the right choice to speed up your recovery. It’s absolutely free – no handcuffing contracts or hidden fees. Just go for it.

Generic Viagra (Sildenafil) 100mg vs Generic Cialis (Tadalafil) 60mg

One of the most decisive indicators of efficiency in ED drugs is the duration of action. Generic Viagra works within up to 4 hours, while Generic Cialis provides an up to 36 hours effect on sexual function (that’s why it is also nicknamed as ‘weekend pill’). Cialis is more comfortable in the use from the prospect of its prolonged action given the fact that it doesn’t stimulate erection, but enhances the natural body reaction. Plus the patients should keep in mind that Viagra cannot be taken more frequently than once each 24 hours.

Although both preparations inferior to Levitra formulation as for ingestion speed, Cialis is still better than Viagra. It is taken 20 – 30 minutes prior to the anticipated intercourse, while Viagra is better taken 45 – 55 minutes before the planned sex.

Another crucial aspect is compatibility of drugs with meals and alcohol. The medicinal effect of Viagra is greatly reduced when receiving fatty foods, so it is highly recommended to be taken on an empty stomach. Simultaneous use of alcohol can weaken the effect of Viagra and aggravate the possible adverse reactions. At the same time the therapeutic action of Cialis is almost unimpacted by meals and alcohol, though it is better to limit the consumption of both to minimum.

The drug’s half-life is an important factor for people suffering from cardiovascular and renal diseases. The shortest half-life ranging from 3 – 5 hours is observed in Viagra, so the drug could be a more suitable option for those having cardiovascular issues, especially against the background of Cialis half-life that equals 18 hours. Talking about diseases, Cialis is highly likely to be more effective in diabetes patients – the results are statistically better than Viagra by 11 – 18%.

Side effects are more frequently reported in the use of Viagra, and such reaction as changed color perception is noted in Viagra only. In general, the manifestation of side effects is approximately 7 – 19% more likely in Viagra than in its rivals, including Cialis. Finally, the optimal dosage of Viagra varies from 50 to 100 mg of active substance; while in Cialis it is reasonable not to exceed the maximum dosage of 20mg, so Cialis might be a slightly more cost-effective option.

When You Should Better Seek for Alternatives

The drug is contraindicated in case of hypersensitivity. Neither Generic Viagra nor Cialis should be taken in those on permanent or intermittent course of nitric oxide donators, which is explained by the fact that sildenafil enhances the hypotensive effect of nitrates. The medication should be taken with caution in patients with anatomical deformation of penis (including the angulation, cavernous fibrosis or Peyronie’s disease), diseases predisposing to priapism (such as sickle cell anemia, multiple myeloma, leukemia, thrombocytopenia), and diseases accompanied by bleeding, with acute gastric ulcer and duodenal ulcers, hereditary retinitis pigmentosa, heart failure, unstable angina, adjourned over the last 6 months of myocardial infarction, stroke, severe, life-threatening arrhythmias, hypertension (blood pressure more than 170/100 mm Hg .st.) or hypotension (blood pressure less than 90/50 mmHg).