Priligy (Dapoxetine) – All information, How to use, Contraindications, Side Effects and Benefits Tips, Where to buy online

Priligy (Dapoxetine)
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Product name Priligy (Dapoxetine)

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Category Men's Health, Premature Ejaculation
Active ingredient Dapoxetine
Avaliability In Stock
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What is Priligy used for?

Priligy is an oral medicine used to treat a marked premature ejaculation (PE) in men aged between 18 and 64. PE is manifested as having an ejaculation before having completed a mutually satisfying sexual act, or before either of the partners would like it to occur. This issue is known for causing shortcomings in sexual life and relationships, as well as set grounds for frustration and complexes. When a man experiences orgasm with too little sexual stimulation, before penetration occurs or shortly after it and has a problem controlling or postponing this process, one can talk about PE.

Priligy contains dapoxetine hydrochloride, the main medicinal component that helps to postpone the moment of ejaculation in a way that is desirable for the patient. The drug gives an ultimate control over coital length and duration, essentially improving the quality of the sexual experience in both partners. Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) preparation that affects and balances the levels of serotonin in the brain, thereby providing a centralised action.

What is unique about Priligy?

Priligy maximal benefits tips

Priligy is a unique drug by the very definition; it is the first-ever solution for PE to have hit the market. Ever since the time the preparation was introduced and became available for customers, it’s been a major game-changer. No more frustration and performance anxiety associated with inability to conduct a sexual act for a period of time long enough to satisfy a partner. Contrarily to a popular belief, premature ejaculation is not a condition that befalls only young men in their teens; it is an issue that can be equally found in mature patients of varied age groups.

Since this problem is closely connected to the psychological condition of a patient, but also being largely dependent on the chemical balance of the brain, thyroid conditions, hormonal imbalance, urological problems, hereditary patterns and traumas, dapoxetine contained in Priligy is an ideal solution to correct this disappointing behaviour.

Priligy is available as a generic solution, to give you a fair choice when it comes down to picking a brand over generic or vice versa, based on how much you are willing to pay for the name of the manufacturer. Generic edition does not differ from the brand one in any essential way but the name, the appearance and, of course, the price factor.

What is premature ejaculation?

Premature ejaculation is also called premature ejaculation. This occurs most often in sexual dysfunctional men and, at one point or another, occurs between 20 and 40% of all men worldwide. A significant number of men believe that impotence and premature ejaculation are related, but there are both major differences – both physiologically and therapeutically. The medical treatment against sexual dysfunction in the form of premature ejaculation is dapoxetine, which is basically an antidepressant.

In the past, the cause of premature ejaculation was always found by a mental illness or physical impairment. However, recent studies have made up with the old, superficial diagnoses and have instead found the cause of the neurons.

Serotonin is considered to be the messenger among the neurotransmitters who decide when a man ejaculates. The so-called 5-HT2c receptors ensure postponement of men’s release. If there are not enough drugs to affect the receptors, you will not experience premature ejaculation. Another factor is that the 5-HT1A receptors stand to ensure the correlation between release and orgasm in men. However, this area may also be affected by unlearned protein to stimulate these receptors. If there is not enough drug to affect the receptors, it will be almost impossible to get an orgasm.

Dapoxetine – the active ingredient in Priligy

DapoxetineDapoxetine is the first approved drug for premature ejaculation. On average, dapoxetine makes 2 to 3 times so far for the many Danes who experience this disorder. There is not a particular population that suffers from this condition. It affects more parts of the population, but fortunately there is an effective treatment for the suffering. Dapoxetine is the active substance in the product Priligy. It is usually prescribed for men between 18 and 64 years of age against premature ejaculation. The active ingredient has been on the market since 2009 and in this long period since launch, no similar substance has been approved.

Dapoxetine (chemical name: (+) – N, N-dimethyl-1-phenyl-3- (1-naphthyloxy) propylamine) belongs to a group of selective serotonin inhibitors (SSRIs) and ensures that serotonin production in the body is temporarily suppressed. Depending on the patient, it is possible to extend the time from penetration to ejaculation by 300%. The pill should only be taken once a day, approx. 1 to 3 hours before intercourse. Since dapoxetine is not a vital treatment, but a lifestyle, the cost of dapoxetine is not covered by the health insurance.

Dapoxetine effects

Dapoxetine affects the serotonin in the body. Dapoxetine blocks the transport molecules that normally transport serotonin around the body. Dapoxetine therefore ensures that there is a lower concentration of serotonin in the brain, so that a larger amount of neurotransmitters continue to circulate in the body.

This means that you can maintain the excitement during intercourse for a long time. This increases the amount of unbound serotonin in the cerobrospinal fluid and therefore exposes the orgasm in men. That way, you will affect premature ejaculation on several parameters.

The inclusion of serotonin in the body is the main cause of men’s orgasm. When the body does not absorb serotonin, the orgasm will be exposed.

The effect of Dapoxetine varies between 60 and 180 minutes after ingestion of the pill. The pill therefore works quickly and this makes it ideal for treating premature ejaculation.

However, unlike other SSRIs, the duration will be much shorter because the drug is in the body for a relatively short period of time. The half-life is rapid, so effect time is affected, but on the other hand, the risk of side effects is also significantly reduced.

How is Priligy taken?

Priligy is a drug for oral administration. Your prescriber will start dapoxetine therapy with the minimal dose of Priligy 30mg and increase it in case of necessity as your therapy advances. It is recommended to take a dose of Priligy between 1 and 3 hours prior to the anticipated sexual activity. Take a pill with a full glass of water; do not crush it in your mouth or chew it. Swallow a tablet whole. Choose to take the pills with or without food based on how well you tolerate the drug taken on an empty stomach.

The drug is not intended for an extended therapeutic course. Do not take more than one single recommended dose of Priligy within the 24 hours’ period. Priligy is only taken before engaging in sexual activity. The dosage should only be established by the prescriber and only increased in the event of insufficiency of the precedent dose and given that no major adverse events were manifested during the implementation of a lower dose.

Make sure you see your practitioner at least every six months in case you take Priligy continuously. There is no data as for the long-term effects of dapoxetine in patients taking the drug regularly for a prolonged period of time (lasting longer than 24 weeks).

How does Priligy work?

Priligy belongs to the class of serotonergic drugs called SSRIs, selective serotonin reuptake inhibitor. Dapoxetine found in the structure of Priligy inhibits the activity of the transporter proteins that normally removes serotonin from synapse gap. The drug thereby gives rise to an enhanced serotonergic activity. Serotonergic effect is probably stronger than the tricyclics, excluding Anafranil / clomipramine. It exhibits no or little effect on the norepinephrine transporter, or cholinergic, histaminergic, and noradrenergic receptors, nor any direct effect on serotonin receptors.

Serotonin is a neurotransmitter in the body as in the gastrointestinal tract, in the platelets and in central nervous system. Serotonin in the gastrointestinal tract regulates bowel movements while serotonin in neurons of the central nervous system has a number of functions, including regulate mood, appetite and sleep, as well as affect cognitive functions such as memory and learning.

SSRIs are considered to increase the extracellular (outside the cell) level of the neurotransmitter serotonin into synapses in the central nervous system by preventing or delaying its reuptake. This causes the nerve impulses that are transmitted with the signal substance is enhanced. Serotonin is a neurotransmitter that enhances the feeling of well-being, which thus means that the patient’s perception of their situation changes in a more positive direction.

By levelling the amount of serotonin, dapoxetine increases ejaculatory latency. Intravaginal ejaculation latency time is thereby increased and can be extended for as long as it appears satisfactory for the patient to postpone the moment of orgasm. Priligy acts only as a pre-coital solution, not providing a long-term recovery effect with a continuous use.

Priligy vs. other antidepressants for PE

Priligy is a medicine that helps men who experience their release prematurely during intercourse and more specifically, it belongs to a class of medicine known as selective serotonin reuptake inhibitors also known as SSR, which acts as a retardant . Thus, by the ingestion of the inhibitor, the imminent ejaculation is delayed to the great benefit of both the male and female part of the community.

Priligy was initially developed to treat depression, but today the medication has been re-marked so it is now approved as a preparation for early premature ejaculation. This remark is due to the sudden occurrence of the product’s possibilities, as its effectiveness and safety in terms of inhibition of man’s release had an unprecedented high level. For this reason, today, only Priligy (dapoxetine) can be used for the treatment of premature ejaculation, while the medication has not yet been approved for the treatment of depression, and this also explains exactly where the drug has its strengths.

In the meantime, more and more doctors appoint common antidepressant drugs for the treatment of premature ejaculation, and there are still doctors who follow this method, but today there has been a specific drug for the delay of the man’s release in the form of Priligy. This is far more effective, why it has naturally become the most widely used means for men with early ejaculation.

In practice, Priligy as a retardant that enters and delays the man’s orgasm and ejaculation. It should be mentioned that there is an explicit difference between the previously used general antidepressant medication and today’s Priligy, as Priligy is absorbed and eliminated from the body much faster than drugs that target depression.

In fact, Priligy is absorbed and eliminated within a few individual hours, whereas classic antidepressant medicine will often take several days to be absorbed and eliminated from the body, meaning that if you only suffer from premature ejaculation and thus do not have any problems with depression or similar, Priligy will be a much more effective and healthier drug for you to take.

Priligy Dosage

The drug is available in two dosage forms of 30mg and 60mg. It is recommended to initiate the treatment with dapoxetine at the lowest dose of Priligy 30mg. If this proves to be insufficiently effective and given that the previous dose is well tolerated. Increase your dose only in case your prescriber approves. A dose increase to Priligy 60mg provides additional risks of increased side effects. It is not allowed in persons with underactive CYP2D6 metabolizer function.

Canadian Pharmacy expert tips on Priligy

Priligy should be taken shortly one hour before intercourse and the drug then has an effect for between 1-3 hours. Priligy is available in two different strengths of 30 mg and 60 mg, respectively. It is recommended that you start with the lowest dose to see how the medicine works on your body. For most men, a dose of 30 mg of Priligy is enough to have the desired effect on your body. Your dose can then always be increased if the lowest dose is not effective enough, and in that case you choose a higher dose the next time you shop at My Canadian Pharmacy Rx.

As with any other prescription drug, you may potentially be affected by some side effects when taking your medicine. However, this can usually be avoided if you are careful about which dose you choose to buy. Of course, it is about finding the dose that best suits you and your body, which may be hard to know if you have not tried the medicine before.

The main rule, however, is that you should not buy the highest dose for the first time simply because of the potentially higher efficiency and success rate. Although the effect may be higher, the side effects will also be. There is no need to take the highest dose if a dose of 30 mg is enough to solve your early-challenge issues. So, the best thing you can do is start with the lowest dose and see how your body responds.

It is possible that you will experience the following side effects when taking Priligy: nausea, headache, diarrhea, dizziness. You can ask your doctor for side effects at Priligy before you buy it online. Our patient guidance is also available on phone and e-mail if you have questions about the product.

Please note that if you order Priligy for the first time through My Canadian Pharmacy Rx, and this is the first time you need to take the medicine, you can only get a dose of 30mg. The dose can then be adjusted according to the effect as well as any side effects during your first treatment.

Priligy contraindications

Priligy should only be used in individuals in whom intravaginal ejaculatory latency time is less than 2 minutes, as well as those experiencing recurring and repeating PE issues that provoke ejaculating before the penetration or within two minutes after it, causing the patient’s distress or interpersonal difficulty as a result of the condition. The drug should not be taken outside of the age group between 18 and 64 and is only recommended when the persistency of PE occurrence was manifested with every sexual attempt during a period of the recent 6 months.

Priligy is contraindicated for the use in patients with the following conditions:

• Arrhythmias and conduction disorders;
• Heart failure;
• Heart disease, including syncope history;
• Bipolar disorder;
• Mania;
• Depression;
• Liver disease.

The list of Priligy contraindications given here is not complete. You should ask your physician for a more elaborate list of conditions that are incompatible with the use of Priligy before you start your therapy.

Priligy and other drugs

There is a number of medicines, concomitant use of which with Priligy is not allowed. Below you will find some basic guidelines as to which drugs to avoid while taking dapoxetine preparation. However, this list is not a complete manual but rather an outline, so consult your practitioner for more details. You should also inform your prescriber if you are currently taking or plan to take in the future alongside with Priligy any other medicines, be it prescription drugs, OTCs, herbal solutions, vitamins and food supplements.

Monoamine oxidase inhibitors (MAOIs);
• Thioridazine;
• St. John’s Wort;
• Other SSRIs;
• Norepinephrine reuptake inhibitors (SNRIs) – L-tryptophan, triptans, tramadol, linezolid, lithium;
• CYP3A4 inhibitors (drugs containing such medicinal components as ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazadone, nelfinavir, atazanavir);

• Medicines lowering blood pressure, such as nitrates, alpha blockers, adrenergic receptor antagonists, ED drugs, etc.);
Priligy is incompatible with ethanol, therefore simultaneous use of dapoxetine and alcohol is prohibited.

Priligy side effects

Priligy side effects

Priligy generally features mild side effects. Is, however, in a high percentage (20-50%) cause sexual dysfunction (anorgasmia, decreased libido, ejaculatory latency extended), which can be a significant concern, especially when long term therapy. Sometimes, but not always, reduce the sexual side effects with time, despite continued medication. Provides initially often nausea, and sometimes anxiety reinforcement; These side effects tend to subside with time.

Other adverse reactions:

• Sweating;
• Sleep disorder;
• Weight gain;
• Weight loss.

Chemical properties of dapoxetine (generic Priligy)

Dapoxetine is a white powder with a bitter taste. It is a Naphthyloxyphenylpropanamine derivative that is soluble in water. Dapoxetine is less resistant to the drug flouxetine. The short half-life of the drug means that it is only present in the body for one to two hours. This means that there is much less risk of side effects.

Dapoxetine may be used against premature ejaculation in a man if:

  • Ejaculation occurs within 2 minutes.
  • Man has little control or poor control over one’s orgasms.
  • Automatic ejaculation occurs at low sexual stimulation.
  • Repeated failure to complete sexual intercourse is observed.

Early ejaculation is of course a subjective parameter, but experts have determined that ejaculation within 2 minutes after intercourse is premature.

Priligy maximal benefits tips

Your physician should appraise the benefits of dapoxetine therapy in your individual case after 6 weeks of use, but no sooner than 6 consecutive intakes of the drug, to determine the prevalence of the benefits over the risks. The only effect in terms of the difference between the various SSRIs that can be considered to be proven is that Prozac / Seroscand often give weight loss than weight gain; for other drugs, weight loss and weight gain about as common. Prozac / Seroscand also substantially longer half-life than other preparations, which can be both a drawback and advantage.

Moreover, many clinicians the impression that the various SSRIs certain extent different from each other in terms of both effectiveness and side effects, but no such difference is not considered to be scientifically documented.

Dapoxetine clinical studies

Dapoxetine effect on premature ejaculation has been demonstrated in several international studies. Here it was investigated how effective the drug could expose semen during intercourse. These results confirm other studies from 2015 and 2014. Several studies confirm the effect of dapoxetine on a man’s performance anxiety that affects a man’s erection and release in general. Dapoxetine helps the man relax and reduce stress levels – especially during sex. The study also showed that men taking dapoxetine have much better control over their release.

Dapoxetine has been extensively tested during several studies. Side effects are often mild and temporary, and because the medicine is prescription, one should expect one whose risk of side effects.

However, we are all different, and therefore some will be able to take a high daily dose without side effects, while others will experience side effects at self doses. A 2011 medical examination tested 6,000 volunteers from 25 different straight and therefore you have a good overview of the risk of side effects. The most common side effects of dapoxetine are nausea, dry mouth, headache, diarrhea and insomnia.

Dapoxetine is an antidepressant and it is normal that antidepressants affect the desire for sex. However, a continuous study of the effect on the desire for sex in which Dapoxetine was compared with a placebo overdose. Here it turned out that dapoxetine had little effect on the desire for sex.

Where can I buy Priligy?

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Priligy FAQ

Q: How often do I need to take Priligy?
A: Priligy is only taken as needed, before anticipated sexual activity. There is no data proving therapeutic benefits of continued scheduled use of the drug. Take one pill of Priligy during the period between 1 and 3 hours prior to engaging sexually to allow for the medicine effects to onset.

Q: What dose of Priligy is right for me?
A: A licensed practitioner should establish a minimal effective and maximal allowed doses for your particular case. It should be appointed proceeding from the results of physical examination, laboratory tests and individual response.

Q: Is Priligy compatible with alcohol?
A: Since Priligy main component is dapoxetine, which is SSRI inhibitor and affects chemicals in the brain, it should not under any circumstances be used in combination with alcohol.

Q: Can I take Priligy and Generic Viagra together?
A: Generic Viagra and Priligy can be used together safely if there are no other contraindications as stipulated by your healthcare practitioner. Since ED is often found as a reason for PE, the two drugs work great together, complementing each other’s action. Viagra is also known to decrease penile sensitivity to a certain extent, it can provide some additional benefits for PE patients.

Q: Priligy not working: what should I do?
A: In the clinical studies, Priligy efficacy was estimated at 68.8% for pills containing 30mg of dapoxetine and 77.6% for pills containing 60mg of dapoxetine. This means that it is not going to work in some individuals, and it is perfectly normal. If you experience no effects of the drug, it is advised to consult more specialised healthcare practitioners, since the true reasons for PE are difficult to establish with precision. With a carefully chosen combined therapy that targets the underlying disease, PE can be successfully overcome, and Priligy can still be part of this conditioning.