Why Malegra FXT (Sildenafil+Fluoxetine) is a Perfect Solution for Erectile Dysfunction and Premature Ejaculation Problems
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- What Malegra FXT Is All about
- Top 2 Active Ingredients of Malegra FXT
- Breakdown of Malegra FXT Key Benefits
- Tips on How to Buy Malegra FXT 100mg
- List of Possible Side Effects Produced by Malegra
- Malegra FXT Among Premature Ejaculation Drugs And Therapies
- Malegra FXT Vs. Malegra DXT: My Canadian Pharmacy Comparison Report
- Common Questions and Answers about Malegra FXT 60mg or 100mg
- Safe use of Malegra in HIV patients?
- What is the main cause of erectile dysfunction?
- Can users have multiple erections when taking Malegra?
- Coping with altered color perception?
- Is Malegra safe for partners to take?
- Is it allowed to use lubrication while taking Malegra?
- How much to take?
- Does Malegra interact with any nitrate-based medication?
- Can OAP’S take Malegra?
- Can its intake be combined with alcohol?
- Is there any expiry date?
- Are there any special recommendations for Malegra?
- What to do if Malegra doesn’t work as expected?
- How this medication should be taken properly?
- Why consult a doctor?
- What are its available strengths?
- When to take Malegra 60 mg?
- Why do men choose Malegra 100 mg?
There currently exist numerous drugs that can help not only to achieve and keep an erection, but also work by stopping premature ejaculation, and Malegra is one of such solutions. Many men are familiar with these erectile problems: those have quite a devastating effect on their sexual lives.
Premature ejaculation happens when men ejaculate earlier than partners want during their sexual intercourse, and it is a widespread complaint because 1 out of 3 men experiences this problem, but if it occurs rarely, you shouldn’t be concerned. Erectile dysfunction is men’s inability to get and keep an erection firm enough to have sex. The good news is that high levels of success for both of these intimate problems are proven when taking Malegra, so that you should get more information about this potent and affordable medication.
What Malegra FXT Is All about
Basically, it is the latest development in the industry of ED treatment products, but its key difference or uniqueness is that Malegra combines 2 production function enhancement mechanisms to help male patients to effectively solve a range of sexual dysfunction problems, forget about premature ejaculation and prolong sexual intercourse.
This medicine belongs to a new generation of drugs with a synergistic effect, and it stands out from the rest of conventional erectile dysfunction treatment methods with its integrated approach and affordable costs in terms of its lucrative price-value ratio. For many men, the price of Malegra is attractive, but the best part is that it outperforms its major competitors in terms of their effectiveness.
Top 2 Active Ingredients of Malegra FXT
The preparation of Malegra FXT is represented by a symbiosis of two active ingredients versus only one in traditional remedies. The first one is sildenafil, which is a key component of Viagra and its different forms. It is a powerful selective inhibitor of PDE5 that can cope with different impotence stages because it works by increasing the blood flow into penile tissues. The second one is Fluoxetine, an antidepressant that naturally extends IV (intravaginal) time and postpones premature ejaculation. It is a traditional and time-tested antidepressant that is used as an efficient tool to fight premature ejaculation.
The main mechanism of Malegra FXT action is based on breaking of PDE5 and corresponding promotion of cGMP. This is what boosts the synthesis of nitric oxide, thus, promoting the productive mechanism of selective expansion of penile arterioles and acceleration of the blood flow into penile cavernous bodies. However, the presence of sexual desire and stimulation is still required for a successful action of this medication. The pharmaceutical formula of Malegra is targeted at different aspects at once, including premature ejaculation, improving psychological perception, and offering a quality and natural erection.
Breakdown of Malegra FXT Key Benefits
If you’re interested in the main benefits that Malegra FXT can offer, they include the following:
- A powerful combination of two active ingredients that enhance the actions of each other, thus, providing users with an incredible synergistic effect.
- Dealing with premature ejaculation effectively.
- Considerable effectiveness for all man impotence forms.
- A fast onset of effect.
- Its positive effect lasts for up to 10 hours.
- Greater price and better effectiveness compared to other popular ED meds.
- Increased libido and productive uplifting.
- It is available without a prescription.
Tips on How to Buy Malegra FXT 100mg
For those patients who want to buy Malegra FX there is no need to bounce from one local pharmacy to another because it can be ordered on the Internet. However, you should be careful when choosing its online provider because not all of them can be trusted. Look for approved and reliable sources that sell authentic and quality ED pills.
List of Possible Side Effects Produced by Malegra
Before taking any new drug everyone wants to learn more about the possibility of experiencing unwanted symptoms. Around 15% of those men who decide to take Malegra reported some adverse effects. This means that it may cause certain side effects, just like other meds so that you need to be aware of them before starting your ED treatment. The good news is that they are rare, mild and pass away fast. The most common ones include facial flashing, nausea, headaches, diarrhea, nasal congestion, unexpected vision changes, stomach pain, etc. If you experience any of them, you should contact your physician.
Malegra FXT Among Premature Ejaculation Drugs And Therapies
In literature, premature ejaculation is cited as ‘the most common among male sexual dysfunctions’, a problem found among men of all socio-economic levels: so for some authors, ejaculatory precocity can be defined as a sort of ‘democratic sexual dysfunction’. But that is not all: premature ejaculation is not only the most frequent sexual dysfunction in the male world, but also the most difficult to decipher sexual dysfunction in medical and scientific terms. Needless to deny that premature ejaculation is a clear disorder to everyone, but at the same time very complex to be defined in the most just terms: some describe it as a real physical and psychological illness that inevitably affects the intimacy with the partner, creating embarrassing situations.
In premature ejaculation, man is incapable of maintaining a certain voluntary self-control over his own ejaculatory reflex: this is a problem strongly felt by strong sex, since, after a short sexual excitement, the man is not more able to satisfy their own woman.
Premature ejaculation explained by My Canadian Pharmacy Rx andrologists
After the specialist check, the patient will undergo a therapeutic process useful to overcome the unfortunate misunderstanding under consideration. As is well known, premature ejaculation is a mix of vulnerable causal elements of mental, psycho-physical, physical or relational origin.
Each of these problems will have to be addressed individually, as if this was not the case, the ejaculatory precursor of the subject would be fostered: in this regard, therapeutic strategies against premature ejaculation can be summarized in:
- Rehabilitation therapy of the sexologic type
- Pharmacological therapy
- Psychodynamic therapy
- Natural remedies
Among the various therapeutic options useful to delay premature ejaculation, circumcision should also be remembered: in fact, hypersensitivity to the glans seems to be an important cause of premature ejaculation. Strictly speaking, the doctor may advise the patient for circumcision associated with glandular neurotomy, which is useful in decreasing the sensitivity to the throat, thus postponing ejaculation.
Psychological therapy. Many elements thought to be responsible for premature ejaculation have psycho-sexual origin: as a consequence, the best therapeutic approach to overcome this unpleasant misunderstanding is represented by sexual sex rehab. From the writings of Dr. A. Graziottin, important conclusions emerged: first, sexologic rehabilitation therapy is useful to monitor not only anxiety, but also, and above all, bodily perceptions, those physical sensations useful to control ejaculation, hence to postpone as much as possible the so-called – and already discussed – ‘point of no return’.
In order to (re)acquire a good mastery of one’s own body, this therapy consists of manual practices (masturbation) associated with respiratory education designed to dissolve tension and muscles. Targeted auto massage, yoga, and muscle training also help control ejaculation times. But not only: Through the rehabilitative-sexologic therapy, the premature ejaculation will be able to progressively ‘feel’ his body, to begin to love him and to listen to his own impulses, gesturing. It must be the mind to drive the body, never vice versa.
Psychodynamic therapy. Of all, psychodynamic therapy is perhaps the most complex, since it is designed to decode the patient’s psyche, to discover that ‘mental illness’ that is externally reflected on the physical, that psychological discomfort that prevents man from fully enjoying his sexuality. Through this inner analysis and this self-seeking, the patient learns to recognize and manage their own mistakes: the awareness of the basic problem helps to strengthen man, both psychologically and physically, thus acquiring complete mastery of your body. Many men taking the psychodynamic therapeutic pathway make their mistakes a point of strength, a stimulus from which to start from scratch, in search of new, cleaner sexuality, torn apart by anxieties, fears and tensions that are sometimes totally unfounded. Of course, the partner plays a key role in this case as well: it is imperative that the woman is sensitized and understands the male fragility. It is more than obvious that the woman’s absolute ban on cheating on the partner and using verbal expressions that are heavy or offensive, which would worsen even more ‘unfortunate’ misunderstanding of premature ejaculation.
Pharmacological therapy. The use of medication to correct ejaculation times during a relationship is a highly discussed subject but at the same time a subject of great interest to the medical class. There are controversial theories: some specialists stand against drug administration to delay ejaculation, others are absolutely in favor.
Discrete and joint effects of fluoxetine (Prozac) and sildenafil (Viagra) for PE
Let us understand the reasons for it. According to some authors, to correct premature ejaculation drugs should be avoided not because they are ineffective, but for side effects, which far surpass the hoped-for effects. On the other side of the ideology, there are deployed physicians who are absolutely in favor of the administration of pharmacological specialties for these patients: regardless of the consequences, drugs in fact slow down ejaculatory times.
It appears that ejaculatory precocity is due to functional deficiencies of neurotransmitters, including serotonin: in light of these considerations, it is clear that a drug capable of interacting with serotonin appears to be able to prolong the duration of the relationship, male orgasm. Two useful substances have been isolated in this regard: fluoxetine, a part of Malegra FXT, and paroxetine. This prescription therapy should last for a very long time, even six months, during which the doctor will adjust the dose, progressively decreasing over the course of the months.
Of course, the benefits of pharmacological therapy are amazing and immediate: they allow for better self-control, self-esteem enhancement, and optimization of interpersonal relationships with your partner. On the other hand, the abuse of these drugs could cause considerable anxiety.
As an alternative to fluoxetine and paroxetine, there are vasoactive substances, but only reserved for those patients with severe premature ejaculation, whose choice therapy did not yield satisfactory results. Furthermore, vasoactive substances (e.g. Viagra) may be of great help, especially when ejaculatory precancerity reflects euphoric deficits. In the light of the above it can be concluded, that the combination of sildenafil and fluoxetine found in Malegra FXT improves chances for better health results.
Other possible solutions to prevent premature ejaculation also include local anesthetics: however, these pharmaceutical formulations are useful only in case of hypersensitivity to the gland. It is recommended to use condoms for men who use these local anesthetics to avoid anesthetizing the partner’s genital area.
Premature ejaculation medication is an issue so perceived as controversial: some authors believe that no drugs are needed to treat the disorder, believing that premature ejaculation is the result of an interweaving of anxiety and fears that precede sexual intercourse. Supporters of this line of thought are convinced that the use of drugs for the treatment of the disorder is useless because the side effects outweigh the therapeutic benefits. Other doctors, on the other hand, support the opposite theory, convinced that certain specific drugs cannot only distract the anxiety and worry that afflicts man at that moment, but also and above all control the ejaculatory reflex.
However, it would be incorrect and unwise to generalize: each organism responds in a unique and unique way to the stimuli of any nature, so if a man can overcome the problem with a mere counseling from the specialist, another may need medication to effect ‘Immediate’ to treat this unpleasant, though understandable, sexual disorder.
Before proceeding with drug treatment, the doctor may propose to the patient to undergo circumcision: this practice seems particularly useful in solving the problem for patients with premature ejaculation dependent on hypersensitivity to the gland. Circumcision associated with glandular neurotomy appears to be very effective in postponing the ejaculatory reflex of man, decreasing hypersensitivity to the glands. not to forget also that, according to some thought, circumcision can even enhance sexual pleasure in men.
Malegra FXT: combining chemicals from two groups of drugs used in PE
The following are the classes of medicines most often used in the treatment of premature ejaculation, and some examples of pharmacological specialties. it is up to the physician to choose the active ingredient and the most suitable posology for the patient, depending on the severity of the disease, the health of the patient and his response to the treatment:
Antidepressants: Some antidepressants seem to solve, at least in part, the problem of premature ejaculation. In the light of in-depth scientific studies, it was observed that ejaculatory precocity is heavily influenced by neurotransmitter deficits, such as serotonin. the administration of drugs that can correct the action of these mechanisms can prolong the duration of the relationship by postponing ejaculation. Not by chance, a side effect (here used for therapeutic use) of antidepressants is precisely the ejaculatory delay. Administration of these drugs may cause side effects such as nausea, dry mouth, drowsiness and decreased sexual desire.
Fluoxetine (e.g. Azur, Prozac, Fluoxerene): Generally, the action of this drug, as well as that of other SSRIs, for the treatment of premature ejaculation is observed after more than 10 days of therapy. Consult your doctor.
Paroxetine (e.g. Sereupin, Serestill, Eutimil, Daparox): The drug is a selective serotonin reuptake inhibitor (SSRI), particularly suitable for the treatment of generalized anxiety. The drug is indicated for the treatment of premature ejaculation to relieve anxiety and prolong the time of sexual intercourse. Dosage and duration of therapy should be determined by your doctor.
Sertraline (e.g. Zoloft, Sertralina, Tralisen): This drug, like the former, belongs to the class of SSRIs and is used as an alternative to paroxetine to treat symptoms of premature ejaculation. Again, the dosage and duration of the therapy are only medical issues. Generally, therapy should be continued for at least 6 months, and the first therapeutic effects are appreciated at least 10 days later.
Clomipramine (e.g. Anafrinil): This drug is still being discussed. The drug is a tricyclic antidepressant for use in the treatment of premature ejaculation only after testing an SSRI: if the patient does not benefit the patient after at least a couple of weeks of therapy, it is possible to proceed with cyclopramine, medication more powerful. Generally, the dosage of the drug, which must be determined by the physician, is quite low: it is advisable to take the active substance 3-4 hours before sexual intercourse.
Sildenafil (e.g. Sildenafil Teva, Viagra, Revatio, Vizarsin, Sildenafil Actavis, Sildenafil Ratiopharm): The drug is a type 5 phosphodiesterase inhibitor, which is useful in promoting smooth muscle relaxation. The drug is available as tablets to be taken orally, approximately one hour before the report. Consult your doctor for any clarifications.
As is seen from the above, Malegra FXT belongs to both groups of drugs used for PE at the same time, which drives up its chances for improved health outcomes. Scroll down to learn more about other drug clusters administered for IVELT (intravaginal ejaculatory latency time) prolongation.
Other drugs used in PE
Topical anesthetics: The administration of ointments, creams or gel to anesthetic action directly on the penis may in some way be helpful for man to delay the ejaculatory reflex.
Lidocaine (e.g. Lidoc C FN cream, Xylonor spray, Elidoxil cream, Ortodermina pomata): apply the product as a spray or cream directly on the penis to create the analgesia necessary to delay ejaculation. Consult your doctor. Apache: often analgesic drug is available in combination with lidocaine (e.g. Emla). It is recommended to apply the product locally, 15-20 minutes before starting a report.
Administration of the anesthetic cream penis is not without side effects: among all, the reduction of genital sensitivity and female sexual pleasure. In some cases, although rarely, the application of these ointments may trigger an allergic reaction. In such cases, it is advisable to use the condom just to escape the possibility of creating unpleasant side effects to the woman.
Vasoactive substances: Therapy with these drugs is usually reserved for those patients with severe premature ejaculation, where SSRI administration and / or topical application of analgesic agents have not yielded satisfactory therapeutic effects. More specifically, it is advisable to follow a similar treatment when premature ejaculation is associated with erectile dysfunction.
When premature ejaculation is considered a mild disorder, phytotherapy can be a useful therapeutic option. the drugs and the extracts shown aim to relax the man and to distance the anxiety that often accompanies the discomfort:
- Valeriana (Valeriana officinalis)
- Passiflora (Passiflora Incarnata)
- Linden (Tilia cordata)
Foods rich in bioflavonoids, such as grapefruit, lemon and grapes, seem to be a valuable help to prolong the times of sexual intercourse since they seem to favor the control of ejaculation impulses. Aromatherapy, homeopathy and ayurveda (alternative medicine) to certain extent may be of help to overcome premature ejaculation disorders.
Malegra FXT Vs. Malegra DXT: My Canadian Pharmacy Comparison Report
In this article, My Canadian Pharmacy Rx will try to establish the subtle differences between the two popular men’s health medications, Malegra FXT and Malegra DXT. In order to do this, we will take an in-depth look at how the two drugs compare to each other in clinical trials and how they are practically applied in PE patients. We will start by overview of the two drugs and the therapeutic problem they address.
Premature ejaculation pills Malegra FXT and Malegra DXT
Malegra FXT and Malegra DXT are joint-therapy drugs used in the treatment of premature ejaculation (PE) with or without erectile dysfunction (ED) complication. Both medicines contain sildenafil citrate that addresses the issues with erectile function and sexual act duration. The difference between Malegra FXT and Malegra DXT lies with the second ingredient, which is fluoxetine (the ‘F’ in Malegra FXT) and duloxetine (the ‘D’ in Malegra DXT), both of the substances being well-established antidepressants that are marketed under the names of Prozac and Cymbalta, respectively. Their action is interchangeable, with minor differences that lie, inter alia, in the individual responsiveness and tolerability of the patient.
What is premature ejaculation?
Premature ejaculation represents a very widespread condition in the male sphere. It is estimated that about 25-40% of men suffer from this unpleasant disorder. In other words, about a man on three complains of premature ejaculation problems.
Puberty is a particularly delicate moment, a step in which the boy becomes a man. This transformation is gradual, progressive, certainly not immediate: in similar situations, the mechanism that regulates sperm production is not yet fully functional and established. In this regard, the first ejaculation could occur without any sperm spill or, however, ejaculation could occur at night (night-time pollination). For this very reason, it would not be entirely correct to speak of premature ejaculation in those boys who have just crossed the limit of childhood.
Even though it is a widespread discomfort to what can be believed, premature ejaculation can be overcome. It is a problem that, in the eyes of many men, might appear to be irresolvable, but the remedy is there, so it does not have to scare too much.
In this article we will deepen the diagnostic strategies useful to identify this sensed sexual discomfort. In other words, prognosis (if so can be defined) is excellent when the disorder is diagnosed and treated properly by serious specialists such as andrologists, urologists, sexologists and psychotherapists.
What can ejaculation can be called premature?
Given the high incidence rate of the disorder, premature ejaculation is the subject of study for many authors: unfortunately, however, it is quite complex to trace precisely the clinical criteria that perfectly fit the disorder. In other words, it is very clear how premature ejaculation is manifested, but it is not so immediate and objective that the exact time in which ejaculatory precocity can be considered.
Some authors frame premature ejaculation in terms of thrusts, which express the coital movements useful to the attainment of orgasm. For other authors, premature ejaculation needs to be established considering the time between vaginal penetration and ejaculation. Obviously, neither the temporal parameters, nor the number of cousin movements seem to be useful clinical criteria for objectively and detachedly establishing ejaculatory precursors, as they are not considered the psychological factors that regulate it all.
Despite this, some authors define premature ejaculation when male orgasm ends within 30 seconds of vaginal penetration. Others, however, deny another theory that man can be termed ‘premature ejaculation’ when he reaches orgasmic frenzy before the woman, regardless of the ‘duration’. This latter theory should not be underestimated, considering that man reaches orgasm before the woman in 50% of the cases.
In conclusion, probably none of these theories could really be considered to frame premature ejaculation disorders: some men pass the so-called ‘non-returnable ejaculation point’ already during the preliminary phase, therefore before the actual penetration; not to mention those men who are already ejaculating at the sole view of the partner in intimate attitudes.
From these concepts it can be seen that it is not possible to outline an objective timing about premature ejaculation: it would be wrong to establish ‘right’ times to complete a relationship, as this should always be spontaneous, as well as scattered by rules and ‘palettes’. It is therefore obvious that, by setting preamble or preliminary conditions, man may be conditioned in the negative: sexuality should not have precise patterns, otherwise there is a risk of either consuming the relationship mechanically or stumbling in unpleasant misunderstandings, for example, premature ejaculation given by the will to follow precise pre-established rules.
How is premature ejaculation diagnosed?
In diagnosing premature ejaculation, the specialist needs to consider several factors: in this regard, it is often necessary for the multidisciplinary approach needed to study the psychological, physical, physical, and sexual factors affecting one to the other, others, causing a marked lack of ejaculation control. It is worth remembering that ‘premature ejaculation’ means premature sperm emission: therefore, male affection ends the sexual act just before or immediately after penetration, denying the female partner the opportunity to achieve pleasure.
The time between the moment of pure penetration and sperm emission is an important diagnostic method, known as Intravaginal Ejaculatory Latency Time: this alternative method can also be considered for self-diagnosis. A number of statistical surveys have been carried out, from which it emerged that the average duration of a full sexual relationship (whose starting point must coincide with the time of vaginal penetration) is between 5.5 and 6.5 minutes . Incredible data, considering that 90% of males with premature ejaculation consume the ratio in less than a minute.
The diagnosis must be targeted at the type of premature ejaculation: in the previous articles we distinguished the various forms of ejaculatory precocity. We focus attention on premature ejaculation of the primary type: the disorder can have a presumed genetic origin, consequently it will be the duty of the specialist to educate the man with a greater mastery of his own body, delaying as far as possible the infamous ‘ejaculatory point of no return’, besides which the emission of sperm is inevitable.
Early secondary ejaculation, on the other hand, is more complex because it requires a careful psychological analysis of the affectionate person: in this latter case, the multidisciplinary approach is indispensable since the patient will be required for the seminal fluid culture test, urological and andrological and, ultimately, urethral swelling post-prosthetic massage. These clinical trials are useful in recognizing the nature of the disorder: from the analysis of the aforementioned tests, one can understand, for example, when the patient suffers from premature ejaculation due to a genital inflammation.
But premature ejaculation could conceal effective deficits, both in terms of acquisition and maintenance of erection: meticulous diagnosis helps clarify the causes that have caused it.
After studying the patient from the physical point of view, the psychological approach is useful: often, ejaculatory precocity is born precisely in the psyche, regardless of the presence or absence of physical disturbances. Among all, performance anxiety plays a decisive role in sexual act; not to forget even anedonia, lack of pleasure, and anorgasmia, the impossibility of reaching orgasm. We remember it once again: not for all men, ejaculation coincides with orgasm. Stress and depression, as well as the overuse of drugs – in particular pharmaceuticals against Parkinson’s disease – are factors that contribute to ejaculatory precociousness.
The specialist should not stop at the ‘superficial and apparent’ diagnosis of the subject complaining of premature ejaculation: it is indispensable to accompany her to a psychological investigation that helps the doctor find the most suitable therapy for the patient.
Depending on the diagnosis, patients with ejaculatory precociousness can be divided into two categories: fever hypo-aggressive and pulsating aggressors.
In the first category belong all those who complain of a peculiar characteristic fragility and a noticeable progressive decline in desire; the term ‘fusional’ is related to the allegedly almost morbid connection with the mother – characteristic of these patients – while the term ‘hypoaggressive’ refers to the psychological profile of these men, unknowingly scared by their alleged physical aggression towards women.
Different is the interpretative reading key of those ‘agressive pulsed’ men with premature ejaculation: they represent the exact opposite of the previous category, being energetic and sexually eager to satisfy their own woman. In similar circumstances, premature ejaculation is due to a stage of sexual stasis, where man loses his ability to control himself, and when he resumes the possibility of consuming a relationship, there is also premature ejaculation.
Reporting the two types of patients, fusion hypoaggressives undoubtedly present the category with greater difficulty in re-acquiring the full mastery of their body: in any case, this does not detract from these patients being able to recover completely from premature ejaculation, afterwards obviously, to a targeted diagnostic and therapeutic approach.
Duloxetine vs. fluoxetine in clinical trials
Duloxetine, as well as fluoxetine, is a serotonin reuptake inhibitor and noradrenaline (SNRI) inhibitor and weakly inhibits dopamine reuptake in neuronal synapses. The registered therapeutic indications are: treatment of major depressive disorder, treatment of peripheral neuropathic pain, treatment of generalized anxiety disorder and premature ejaculation treatment. Duloxetine is indicated in adults. In this small excursus we will take on the role of duloxetine in treating depression.
A systematic review investigated the efficacy and tolerability of duloxetine to other antidepressants in the treatment of depression signs, premature ejaculation among them. The review included 16 randomized controlled trials for a total of 5,735 patients and concluded that duloxetine does not appear to provide a significant benefit in terms of effectiveness compared to other antidepressants in treating the acute phase of major depression; it was also worse in terms of acceptability and tolerability than some SSRIs and also with fluoxetine.
The same conclusions came from a systematic review of 2009 that investigated the efficacy and safety of duloxetine in treating the acute phase in major depression. The review analyzed 36 experimental and observational studies without looking at differences in efficacy and safety in favor of duloxetine towards other antidepressants. The authors conclude that in the acute phase of major depression it is not possible to justify the choice of duloxetine compared with other second-generation antidepressants with regard to efficacy and safety.
However, it should be noted that in the literature there are randomized controlled trials comparing duloxetine versus placebo and using some SSRI (fluoxetine or paroxetine) as active control but it should be noted that in these trials duloxetine was used at doses higher than those authorized (more than 60 mg), then off-label.
It is interesting to analyze in more detail the published (only published) studies of duloxetine and fluoxetine unique two exponents of the SNRI class currently available.
The first study evaluated jointly the results of two multicenter, randomized and double-blind trial trials. In these studies, a total of 667 patients were randomized to receive duloxetine 60 mg / day or fluoxetine 150 mg / day (after 2 weeks at 75 mg / day) for 6 weeks. At the end of this period, patients continued treatment for a further 6 weeks, during which the dosage could be increased at the discretion of the experimenter up to 120 mg / day for duloxetine and up to 225 mg / day for fluoxetine.
Two scales were used to evaluate the results:
HAM-D-17 Hamilton Depression Rating Scale: the most commonly used tool to measure the severity of a depressive disorder and improvements in drug therapy designed by Max Hamilton and first published in 1960. The scale contains 17 variables, with scores from 3 to 5, and the evaluation is as follows: less than 7 indicate the absence of depression; 8 to 17 mild depression; 18 to 24 moderate depression; more than 25 severe depression
Montgomery-Asberg Depression Rating Scale: A diagnostic questionnaire composed of 10 items (depressed mood, tension, sleep and appetite disorders, difficulty concentrating, asthenia, loss of feelings, pessimistic and suicidal thoughts) with which you can measure the severity of depressive episodes in adults. The global score, that is, the sum of 10 points overall score, expresses the general severity of the symptom. Items are rated on a 7-point scale (0, absent at 6, maximum gravity), where scores 0, 2, 4, 6 are considered full scores, while others are intermediate scores. which may be useful if symptomatology is less defined; the total score range is 0-60.
The primary objective of the study was to demonstrate the superiority of duloxetine vs. fluoxetine in terms of global risk-benefit (GBR), a composite parameter where benefit was given by achieving remission (HAMD17≤7) and the risk defined in four categories depending on the presence or absence of adverse events. The only efficacy analysis aimed instead to establish the non-inferiority of duloxetine vs. fluoxetine at the sixth and twelfth week in terms of HAMD17 variation compared to the baseline, with a higher margin of not inferiority of 1.15.
Both at the end of the first six weeks and 12 weeks of the study, there were no significant differences in overall risk-benefit (GBR) between the two treatments and duloxetine was therefore not able to demonstrate its superiority. Moreover, in duloxetine efficacy analysis, it exceeded the pre-established limits for non-inferiority (difference 1.72 at the end of the first 6 weeks, 1.91 at the end of 12 weeks). A significantly higher number of patients in the fluoxetine group (74.5%) completed 12 weeks of treatment compared to the duloxetine group (64.8%, p = 0.006).
The second study is a six-week open-label randomized randomized trial that enrolled 228 patients with major depression diagnosis to investigate efficacy and tolerability of duloxetine versus fluoxetine. There was no difference in efficacy between the two antidepressants as a variation on HAM-D and MADRS scales compared to the baseline, while the percentage of adverse events was higher in the arm of the treated duloxetine (65%) than fluoxetine (58%).
From the analysis of evidence, it emerges that duloxetine has no greater efficacy than drugs used for the same indications; in head-to-head studies with other antidepressants was at most not inferior, sometimes even higher doses than those authorized in a comparison study with fluoxetine showed lower. Long-term tolerability has not been sufficiently documented and the data available today suggest that it is even worse tolerated. It should also not be forgotten that in the treatment of elderly people (ages> 65 years) duloxetine has limited evidence.
It can be concluded that in the treatment of serotonin disorders that lead to PE, it is better to prefer an antidepressant with an adequately documented benefit / risk profile such as fluoxetine.
Common Questions and Answers about Malegra FXT 60mg or 100mg
If you have any questions in your mind about the intake of this ED medication, this section will be quite helpful because it contains some of the most important answers.
When taking Malegra patients will have a much faster reaction time if they also use protease inhibitors as a part of their everyday HIV treatment regime. That’s why it is necessary to discuss possible ins and outs with your doctor to get a better understanding of possible interactions associated with HIV-related medications and Malegra.
Once you notice that you can’t achieve a firm erection or your penis doesn’t stay erect when needed, it is worth contacting your physician to be properly examined, diagnosed and tested. That’s because only qualified doctors can help you determine the main cause of this unwanted medical condition, and you should remember that possible triggers vary from one man to another.
Other important information about Erectile Dysfunction read here: www.mycanadianpharmacyrx.com/erectile-dysfunction
It is possible to have them when undergoing this ED treatment, but its likelihood depends on many individual factors, including your age, overall medical condition and so on. In any case, having sex is a part of people’s nature, so you shouldn’t overdo things instead of making this process pleasurable and fun. To stop being concerned about having multiple orgasms is a good tip.
One aspect about taking Malegra is that a visual blue tint is a common adverse effect, so that some patients are worried about coping with it. There is no need to worry about that because a blue tint will subside naturally, and you only have to wait for a while. People use different methods to solve this issue, including making love with lights either dimmed or off.
Malegra is intended for the use in men suffering from a specific set of conditions. There are some people who try different meds to spice up their sexual life, but you should use Malegra only if you suffer from man impotence.
All people should be able to enjoy their sexual intercourse when using Malegra. If you find it easier and more pleasurable to use any lubrication during it, feel free to do that because there are no negative effects associated with this combination.
It is not advisable to take Malegra on a daily basis because it starts working around 30 minutes after its use and remains effective for several hours. Male patients should take one pill when needed, and they shouldn’t be tempted to take the second dose if they don’t see any expected reaction at once, because they will be at risk of overdose.
If you need to take such meds, you are not allowed to use Malegra, because this drug combination will result in a considerable drop in blood pressure that can be complicated to promptly stabilize. Male patients are not recommended to combine this ED medicine with nitrate drugs to avoid severe drug interactions.
According to the latest statistics and studies, men of different age may experience erectile issues. Dose adjustment in older citizens is not required as long as they do not have any comorbidities. In fact, most of men using Malegra belong to an older generation, so that you will find it quite a successful and helpful tool to get back your firm and lasting erections while improving your sexual performance.
Keep in mind that one of the main causes of erectile problems is that men drink too much alcohol before their sexual intercourse. If you want to get the highest success rates when taking Malegra, you should avoid drinking any alcoholic beverages or consume them in moderation. The lower your alcoholic intake is, the higher your chances of having a firm and lasting erection are.
Just like other medications available on market, Malegra has an expiry date that is marked on its packaging. All consumers should take it only if this medication is not expired, so that if its expiry date has passed, it is required to dispose of the whole pack at once.
For any person, it is important to look after the body and its overall health. For example, those who drink or smoke too much are more prone to developing certain erectile problems, so that you should lead a healthy lifestyle, as this is what will enable you to get a better outlook and stay sexually active for longer.
First-time users may not experience the exact type of effects that they have been waiting for. It takes a few doses and time to get used to this medication and get the most out of its use. However, if you have tried Malegra a few times, but you saw that you’re not getting any expected results, then you should switch to other doses or forms. Don’t lose your hope because you will find the right one for your needs.
Malegra starts being active and effective in around thirty minutes after its intake. The time necessary for its activation can be increased if you take your pill with heavy or fatty meals. In addition to that, you should understand that it is not an aphrodisiac, so that it can’t be taken without any prior natural sexual arousal because you will end up with no erection. Without enough sexual stimulation you will only experience increased potency, but any erection won’t occur. Another important fact that should be mentioned is that the action of this effective ED medication is more dependent on your individual predisposition, but there are proven claims that Malegra stays active for around 4 hours.
Before taking this pill, you should consult your physician, especially if you have any chronic medical conditions, including liver, cardiovascular and kidney problems. This step should be taken to ensure that you’re on a safe side and get more information about possible pros and cons.
It is possible to find and buy Malegra in a few different strengths, such as 100/40 mg and 100/60 mg. Most patients take it on 100/40mg mg, but you may choose either higher or lower dose based on your individual response and other important factors, including other meds that you take, current health condition, reactions to its active ingredients, etc.
It is the lowest dose of this ED medication, and patients are advised to take it if they experience certain side effects or use alpha blockers at the same time. This dosage is associated with such benefits as low risk of having adverse effects, high effectiveness rates and a possibility of increasing doses.
It is the biggest dosage of this medicine, and it is taken when men have severe chronic impotence, no allergic reactions and no other medical problems. It comes with such benefits as managing the severest cases and high success ratings.