In the treatment of female infertility it is important to find correct medicine that can stimulate the release of hormones responsible for ovulation. Today there is enough stimulants, but one of the most commonly prescribed is Clomid*, which since 1970s has proven to be effective in the stimulation and regulation of women ovulation. However, you should be totally informed about this drug if you are about to plan out your pregnancy. Because Clomid`s use is associated with several negative outcomes, the most common are low pregnancy rates and thinning of the endometrium.
What is Clomid (Clomiphene)?
Clomid categorised as a SERM or selective estrogen receptor modulator and oestrogen antagonist. It is also known a Clomiphene, Clomiphene Citrate, CC or Clomifene.
Clomiphene is known as a chemical compound since 1956. Due to its stimulating effect on ovarian function it was once acknowledged as a good finding. The early publications with reviews were focused on the clinical experience of the treatment of women with amenorrhea. However, very soon the drug came to be used to overcome infertility, as the pregnancy rate in women undergoing treatment suddenly found much higher than expected. So in 1961 Greenblatt RB et al. have published their observations on the use of Clomiphene in women with anovulatory infertility. And in 1967, clomiphene has been approved by the FDA for the treatment of infertility.
Clomiphene by its action is a non-steroidal selective modulator with good binding ability of receptors of estrogen. You will find it as a white or pale yellow powder, odorless, unstable in air and light.
The effect of this stimulant causes rising of the level of hormones (gonadotropins, FSH, LH) that stimulate the testicles.
- FSH or follicle stimulator causes the eggs in your ovaries to ripen, ready for release.
- LH or luteinise-hormone makes one or more mature eggs moving down from the ovary follicles into one of your fallopian tubes.
The treatment which you interested in can also act in tandem with other medications. Meanwhile Generic Viagra can get improved and long-lasting erections, Clomide stimulates the natural production of testosterone, which is beneficial for athletes, especially during the training period when the testosterone levels are above the norm.
You´re Supposed to Know That…
- Clomid acts the same way as estrogen, which is very important in the process of ovary fertilization;
- Globally, it is still the most widely used of all fertility drugs – it reaches up to 70% from the market. It is sold without medical prescription as well as Viagra in Canada.
- Clomid can be taken in combination with gonadotropic hormones, this info you can find in the instructions for use.
- About 70 % of women will ovulate during the treatment. Of those quantity at least 40% will get pregnancy.
How Does Clomiphene Work?
The stimulant has both estrogenic and anti-estrogenic properties and stands out among its analogues because of a high bioavailability (90%). Clomiphene is well absorbed by the stomach, metabolized by the liver. It is characterized by long-entero-hepatic recirculation and has a half-life period of 5-7 days.
Clomid or as Clomifene etc. appears to stimulate the release of hormones which leads to the production of ovarian follicle, ovulation and function of the corpus luteum, thus resulting in pregnancy.
The main mechanism of action is to break negative feedback loop at the level of endogenous oestrogen receptors of the hypothalamus, which in turn causes an increased release of gonadotropin-releasing hormone from hypothalamic. As a consequence, the levels of FSH and LH also rises up.
How to Use This Medicament?
Treatment needed to be started with a low dose. Normally, it should be given in a dosage of 50 mg daily (1 tablet) for 5 days.
When to begin? Mostly doctors recommend to choose the fifth day of the menstrual cycle. By this time physiological FSH levels decline. That on the one hand provides the conditions for normal competition of enthral follicles and on the other facilitates the selection of a single dominant follicle, After 5 days you must do pause, until the next beginning of your cycle. Then you can wait the same five-dayperiod and then make a new short-course with 25 or 50 mg to start with.
Sometime the dose will be altered for the next cycle in order to ensure that only single egg is released this month. The longest duration of treatment generally should not exceed 6 months. It’s thought to be long enough to see if your body gives a reaction.
The good news are that it is possible to take CC both with and without food without affecting its effects. This medicine is well absorbed orally, during excretion the body looses primarily about 42% and 8% more with urine. The dose should be increased only in case when ovulation still doesn’t come. It is recommended to reduce the dose or make duration of treatment shorter especially if the patient is detected as unusually sensitive to pituitary gonadotropin. That happens, for example, in the presence of polycystic ovary syndrome.
Ovulation occurs most often on the 5th, 6th, 7th day up to 10th, after a five-day course of Clomid. This is the best time, you can try to conceive a child. Use a detector-ovulation test these days.
If your period began later or earlier, start a new course within five days. If it takes too long to start, make a pregnancy test as soon as possible before use the drug.
Why it Didn’t Work?
Unfortunately, there are some women which body develops an absolutely resistance against Clomiphene. It is approved when even after increasing the dose up to 150 mg patient does not ovulating. This is not any death sentence to your desire to become pregnant, so just ask your fertility specialist what other treatment may be open to you.
In some cases ability to make pregnant depends on how your partner acts, how active, multiple and movable are spermatozoids. Visiting Canadian Pharmacy Rx and choosing right treatment for him, you increase the chances of getting pregnant.
Also there is a possibility that low 25-50 mg dose of Clomiphene may not be enough. Your doctor may increase it to help you conceive.
Clomid’s Side Effects
Using this drug can result in more than one egg being released. Another words, it can lead to a greater risk of multiple pregnancies (most likely twins), because often it stimulates more than one mature ovarian follicle to rupture.
Other more common side effects of this sub-fertile treatment are:
- Mood swings, insomnia and emotional destability;
- Hot flushes
- Abdominal pain and discomfort
- Visual spots
- There’s been some ongoing theory that using Clomide may lead to ovarian cancer
- Problems with overweight
- Reduced production of cervical mucous, that means not just you become dry and need to use lubricant, but also this can lower fertility.
Sometimes doctor can prescribe Metformin as an insulin-responding to CC drug. Using it helps to reduce evidence of Clomiphene Citrate.
Symptoms of Overdose
The main symptoms of overdose are:
- blurred vision;
- nausea and vomiting;
- abdominal pain;
- weight gain;
In most cases, the unpleasant symptoms will pass by itself as soon as it stopped using Clomid.
You should that know…
There is a flimsy theory about that 1 in 5 pregnancies conceived with using Clomid have a miscarriage. However reviews of the evidence haven’t supported this as well as cancer risk.
The “Do Not Use” Cases
Read it please before use Clomid! First of all there supposed to be some researches made proving if you are allergic to Clomiphene. In case of present pregnancy using this treatment is dangerous!
Also you should definitely abstain from taking this medicine if you have:
- abnormal vaginal bleeding;
- an ovarian cyst that is not related to PCOS – you will fond more information about this syndrome below;
- If you had or still have liver disease;
- If you have been operated with tumour of your pituitary gland or still have it;
- If you were defined as a patient with some uncontrolled problem with thyroid or adrenal gland;
To make sure Clomid is safe for you, tell your doctor if you have:
- endometriosis or uterine fibroids.
If you already got a baby and feed with breast, you should stop the course of treatment or you shouldn’t begin the new one. Clomiphene can slow milk production and also can pass into breast milk and may harm a nursing baby.
Should I Use It If I Have Natural Fertility?
The drug you buy online Clomiphene Citrate or other pharmaceutical form of Clomid may also be used in cases of unexplained infertility, these treatments are only effective in couples where there is no or infrequent ovulation. In women with regular periods, and therefore regular ovulation, these drugs are no more effective than trying to conceive naturally.
YOU SHOULD NOT USE CLOMID IF YOU ARE PREGNANT!
Clomiphene Citrate Treatment and PCOS
This abbreviation represents Polycystic ovary syndrome. Reviews show that if you have PCOS, there is a chance that Clomide won’t work for you. About 30 % of women with that type of syndrome are resistant to stimulator. This is more common if you tend to be overweight (with BMI higher than 1.25). In that case your doctor should probably begin your treatment with losing some weight, but normally no more than 5% from your body weight.
Clomide Drugs and OHSS
The second particular case is not the antecedent condition but it may cause some big rebound. That calls ovarian hyperstimulation syndrome or OHSS. While receiving too much stimulation ovaries become very swollen and can develop into a serious condition. In some cases doctor advises to his patients to force an ovulation using gonadrophin injection.
Clomid in bodybuilding
The drug is extremely popular in bodybuilding, powerlifting and weightlifting.
It acts as an antiestrogen due to its ability to block the effects of estrogen on the hypothalamus, which sets off a chain reaction:
- It stimulates the production of GnRH (GnRH);
- It increases the production of luteinizing hormone by the pituitary gland;
- It raises the level of hormones that stimulate the testicles;
- It increases the production of testosterone by the testes.
Whether do not restore normal testosterone levels, it is fraught with negative consequences, in particular the considerable losses to gain muscle volume and strength characteristics. The absence or insufficient levels of androgens (such as testosterone) gives the dominant advantages catabolic hormone cortisol. It directly affects protein synthesis in muscle tissue and stimulates the catabolic metabolism. Among bodybuilders, this process is called post-steroid breakdown, because it can destroy almost all the muscle created. Receiving Clomid helps to prevent this process.
Clomiphene Citrate is mainly very effective in bodybuilding, because of its property of lowering estrogen activity in the body which warns:
- development of gynecomastia;
- deposition of fat and formation of fatty folds;
- accumulation of fluid in the body.
In any case, choosing Clomid therapy, you should consult with your doctor and nutritionist.